Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.

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Detalles Bibliográficos
Autores principales: Yeonkyoung Park, Joori Park, Hyun Jung Hwang, Byungju Kim, Kwon Jeong, Jeeyoon Chang, Jong-Bong Lee, Yoon Ki Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/877497130d0f4624acd427291cc0d0a5
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