Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years

Background: With the advances of neoadjuvant chemoradiotherapy, the identification of complete tumor responses, and the reduction of local recurrence even with the adoption of expectant approaches aimed at sphincter preservation, several authors have published results analyzing these aspects with co...

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Autores principales: Humberto Lyra Junior, Luiz Henrique Minatti, João Carlos de Oliveira, Marlus Gerber, Flavia de Novaes Gerber, Daniella Vieira, José Mauro dos Santos
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Publicado: Shiraz University of Medical Sciences 2020
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Acceso en línea:https://doaj.org/article/877592d6d05340d1949f48e86f008930
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spelling oai:doaj.org-article:877592d6d05340d1949f48e86f0089302021-11-14T08:12:17ZAnalysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years2783-243010.30476/acrr.2020.87993.1063https://doaj.org/article/877592d6d05340d1949f48e86f0089302020-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46989_1b208e42066db886eb37ce9a420fba4a.pdfhttps://doaj.org/toc/2783-2430Background: With the advances of neoadjuvant chemoradiotherapy, the identification of complete tumor responses, and the reduction of local recurrence even with the adoption of expectant approaches aimed at sphincter preservation, several authors have published results analyzing these aspects with conflicting results, which require further investigation. Objectives: This study aims to evaluate the anatomopathological changes in surgical specimens of rectal resection due to adenocarcinoma in patients undergoing neoadjuvant therapy, including the complete response rate, in addition to estimating the sensitivity and specificity indexes of the imaging methods used in the preoperative period. Methods: This was an observational, retrospective, cross-sectional study in which 44 medical records of patients with cancer of the middle and lower rectum who underwent neoadjuvant chemoradiotherapy and subsequently underwent oncological surgical resections over 10 years were studied. Demographic data, CT scans, colonoscopies, anatomopathological reports and surgical reports were analyzed. Results: Abdominoperineal resection of the rectum (APR) was performed in 16 cases (36.4%), and abdominal rectosigmoidectomy (AR) was performed in 28 cases (63.6%). Preoperative computerized tomography (CT) showed a sensitivity of 75% and specificity of 77.8% for the detection of lymph node metastases. The complete pathological response to neoadjuvant chemoradiotherapy was found in 11.36% of cases. The local recurrence was detected in 23.9% cases and distant metastasis in 15.2% of the patients on the follow-up period, additionally, there was a 77.7% 5-years disease-free survival and the overall survival was 73.9%. Conclusions: The rate of complete pathological response to neoadjuvant therapy was 11.36%. Locally advanced disease and angiolymphatic embolization were associated with a higher frequency of lymph node involvement. CT obtained high rates of sensitivity and specificity for comparison with anatomopathological results.Humberto Lyra JuniorLuiz Henrique MinattiJoão Carlos de OliveiraMarlus GerberFlavia de Novaes GerberDaniella VieiraJosé Mauro dos SantosShiraz University of Medical Sciencesarticlecolorectal neoplasmsneoadjuvant therapyrectal neoplasmsorgan preservationMedicineRENIranian Journal of Colorectal Research, Vol 8, Iss 3, Pp 141-147 (2020)
institution DOAJ
collection DOAJ
language EN
topic colorectal neoplasms
neoadjuvant therapy
rectal neoplasms
organ preservation
Medicine
R
spellingShingle colorectal neoplasms
neoadjuvant therapy
rectal neoplasms
organ preservation
Medicine
R
Humberto Lyra Junior
Luiz Henrique Minatti
João Carlos de Oliveira
Marlus Gerber
Flavia de Novaes Gerber
Daniella Vieira
José Mauro dos Santos
Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
description Background: With the advances of neoadjuvant chemoradiotherapy, the identification of complete tumor responses, and the reduction of local recurrence even with the adoption of expectant approaches aimed at sphincter preservation, several authors have published results analyzing these aspects with conflicting results, which require further investigation. Objectives: This study aims to evaluate the anatomopathological changes in surgical specimens of rectal resection due to adenocarcinoma in patients undergoing neoadjuvant therapy, including the complete response rate, in addition to estimating the sensitivity and specificity indexes of the imaging methods used in the preoperative period. Methods: This was an observational, retrospective, cross-sectional study in which 44 medical records of patients with cancer of the middle and lower rectum who underwent neoadjuvant chemoradiotherapy and subsequently underwent oncological surgical resections over 10 years were studied. Demographic data, CT scans, colonoscopies, anatomopathological reports and surgical reports were analyzed. Results: Abdominoperineal resection of the rectum (APR) was performed in 16 cases (36.4%), and abdominal rectosigmoidectomy (AR) was performed in 28 cases (63.6%). Preoperative computerized tomography (CT) showed a sensitivity of 75% and specificity of 77.8% for the detection of lymph node metastases. The complete pathological response to neoadjuvant chemoradiotherapy was found in 11.36% of cases. The local recurrence was detected in 23.9% cases and distant metastasis in 15.2% of the patients on the follow-up period, additionally, there was a 77.7% 5-years disease-free survival and the overall survival was 73.9%. Conclusions: The rate of complete pathological response to neoadjuvant therapy was 11.36%. Locally advanced disease and angiolymphatic embolization were associated with a higher frequency of lymph node involvement. CT obtained high rates of sensitivity and specificity for comparison with anatomopathological results.
format article
author Humberto Lyra Junior
Luiz Henrique Minatti
João Carlos de Oliveira
Marlus Gerber
Flavia de Novaes Gerber
Daniella Vieira
José Mauro dos Santos
author_facet Humberto Lyra Junior
Luiz Henrique Minatti
João Carlos de Oliveira
Marlus Gerber
Flavia de Novaes Gerber
Daniella Vieira
José Mauro dos Santos
author_sort Humberto Lyra Junior
title Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
title_short Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
title_full Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
title_fullStr Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
title_full_unstemmed Analysis of Rectal Neoplasms Operated After Neoadjuvant Therapy in A Period of 10 Years
title_sort analysis of rectal neoplasms operated after neoadjuvant therapy in a period of 10 years
publisher Shiraz University of Medical Sciences
publishDate 2020
url https://doaj.org/article/877592d6d05340d1949f48e86f008930
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