Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity

Abstract The development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low...

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Autores principales:	Qun Wang, Peng Ji, Yansheng Yao, Yi Liu, Yajie Zhang, Xianglong Wang, Yuhang Wang, Jinyan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8778e6fc6d184696822e6ef9ba4fbf91
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spelling	oai:doaj.org-article:8778e6fc6d184696822e6ef9ba4fbf912021-12-02T15:42:59ZGliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity10.1038/s41598-021-89813-02045-2322https://doaj.org/article/8778e6fc6d184696822e6ef9ba4fbf912021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89813-0https://doaj.org/toc/2045-2322Abstract The development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low toxicity. The ZnO/WG hybrid nanospheres were environment-friendly integrated by molecular self-assembly co-precipitating and freeze-drying transformation, and were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic absorption spectroscopy (AAS), specific surface and pore size analysis, bacteriostasis test, reactive oxygen species (ROS) determination and safety evaluation. It was found that the prepared hybrid nanospheres were composed of two components, WG and ZnO, with a diameter scope of 100–200 nm; the content of ZnO in the hybrid nanospheres can reach 46.9–70.2% (w/w); the bacteriostasis tests proved that the prepared ZnO/WG nanospheres generating ROS, have a significant inhibitory effect on E. coli and S. aureus; furthermore, the ZnO/WG nanospheres are relatively safe and highly biocompatible in cells and mice. Therefore, the prepared novel ZnO/WG hybrid nanospheres were supposed to apply in the preparation of anti-infective wound dressings, tissue engineering skin scaffold materials, food, and cosmetics preservatives, and so on.Qun WangPeng JiYansheng YaoYi LiuYajie ZhangXianglong WangYuhang WangJinyan WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qun Wang Peng Ji Yansheng Yao Yi Liu Yajie Zhang Xianglong Wang Yuhang Wang Jinyan Wu Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
description	Abstract The development of inorganic antibacterial agents that impart antibacterial properties to biomaterials has attracted wide attention. The paper introduced a kind of hybrid nanosphere antibacterial agent composed of wheat gliadin (WG) and zinc oxide (ZnO), with antibacterial efficacy and low toxicity. The ZnO/WG hybrid nanospheres were environment-friendly integrated by molecular self-assembly co-precipitating and freeze-drying transformation, and were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic absorption spectroscopy (AAS), specific surface and pore size analysis, bacteriostasis test, reactive oxygen species (ROS) determination and safety evaluation. It was found that the prepared hybrid nanospheres were composed of two components, WG and ZnO, with a diameter scope of 100–200 nm; the content of ZnO in the hybrid nanospheres can reach 46.9–70.2% (w/w); the bacteriostasis tests proved that the prepared ZnO/WG nanospheres generating ROS, have a significant inhibitory effect on E. coli and S. aureus; furthermore, the ZnO/WG nanospheres are relatively safe and highly biocompatible in cells and mice. Therefore, the prepared novel ZnO/WG hybrid nanospheres were supposed to apply in the preparation of anti-infective wound dressings, tissue engineering skin scaffold materials, food, and cosmetics preservatives, and so on.
format	article
author	Qun Wang Peng Ji Yansheng Yao Yi Liu Yajie Zhang Xianglong Wang Yuhang Wang Jinyan Wu
author_facet	Qun Wang Peng Ji Yansheng Yao Yi Liu Yajie Zhang Xianglong Wang Yuhang Wang Jinyan Wu
author_sort	Qun Wang
title	Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
title_short	Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
title_full	Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
title_fullStr	Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
title_full_unstemmed	Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
title_sort	gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8778e6fc6d184696822e6ef9ba4fbf91
work_keys_str_mv	AT qunwang gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT pengji gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT yanshengyao gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT yiliu gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT yajiezhang gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT xianglongwang gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT yuhangwang gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity AT jinyanwu gliadinmediatedgreenpreparationofhybridzincoxidenanosphereswithantibacterialactivityandlowtoxicity
_version_	1718385818561675264

Gliadin-mediated green preparation of hybrid zinc oxide nanospheres with antibacterial activity and low toxicity

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