A genetic basis for the variation in the vulnerability of cancer to DNA damage

The variability in patient response to radiation treatment is difficult to predict. Here, using more than 500 cell lines the authors measure response to radiation exposure and a large panel of compounds, and show that response can be predicted by genetic alterations of the cells.

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Autores principales:	Brian D. Yard, Drew J. Adams, Eui Kyu Chie, Pablo Tamayo, Jessica S. Battaglia, Priyanka Gopal, Kevin Rogacki, Bradley E. Pearson, James Phillips, Daniel P. Raymond, Nathan A. Pennell, Francisco Almeida, Jaime H. Cheah, Paul A. Clemons, Alykhan Shamji, Craig D. Peacock, Stuart L. Schreiber, Peter S. Hammerman, Mohamed E. Abazeed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/877ae97e5e624e97832802165a437654
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spelling	oai:doaj.org-article:877ae97e5e624e97832802165a4376542021-12-02T14:38:35ZA genetic basis for the variation in the vulnerability of cancer to DNA damage10.1038/ncomms114282041-1723https://doaj.org/article/877ae97e5e624e97832802165a4376542016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11428https://doaj.org/toc/2041-1723The variability in patient response to radiation treatment is difficult to predict. Here, using more than 500 cell lines the authors measure response to radiation exposure and a large panel of compounds, and show that response can be predicted by genetic alterations of the cells.Brian D. YardDrew J. AdamsEui Kyu ChiePablo TamayoJessica S. BattagliaPriyanka GopalKevin RogackiBradley E. PearsonJames PhillipsDaniel P. RaymondNathan A. PennellFrancisco AlmeidaJaime H. CheahPaul A. ClemonsAlykhan ShamjiCraig D. PeacockStuart L. SchreiberPeter S. HammermanMohamed E. AbazeedNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian D. Yard Drew J. Adams Eui Kyu Chie Pablo Tamayo Jessica S. Battaglia Priyanka Gopal Kevin Rogacki Bradley E. Pearson James Phillips Daniel P. Raymond Nathan A. Pennell Francisco Almeida Jaime H. Cheah Paul A. Clemons Alykhan Shamji Craig D. Peacock Stuart L. Schreiber Peter S. Hammerman Mohamed E. Abazeed A genetic basis for the variation in the vulnerability of cancer to DNA damage
description	The variability in patient response to radiation treatment is difficult to predict. Here, using more than 500 cell lines the authors measure response to radiation exposure and a large panel of compounds, and show that response can be predicted by genetic alterations of the cells.
format	article
author	Brian D. Yard Drew J. Adams Eui Kyu Chie Pablo Tamayo Jessica S. Battaglia Priyanka Gopal Kevin Rogacki Bradley E. Pearson James Phillips Daniel P. Raymond Nathan A. Pennell Francisco Almeida Jaime H. Cheah Paul A. Clemons Alykhan Shamji Craig D. Peacock Stuart L. Schreiber Peter S. Hammerman Mohamed E. Abazeed
author_facet	Brian D. Yard Drew J. Adams Eui Kyu Chie Pablo Tamayo Jessica S. Battaglia Priyanka Gopal Kevin Rogacki Bradley E. Pearson James Phillips Daniel P. Raymond Nathan A. Pennell Francisco Almeida Jaime H. Cheah Paul A. Clemons Alykhan Shamji Craig D. Peacock Stuart L. Schreiber Peter S. Hammerman Mohamed E. Abazeed
author_sort	Brian D. Yard
title	A genetic basis for the variation in the vulnerability of cancer to DNA damage
title_short	A genetic basis for the variation in the vulnerability of cancer to DNA damage
title_full	A genetic basis for the variation in the vulnerability of cancer to DNA damage
title_fullStr	A genetic basis for the variation in the vulnerability of cancer to DNA damage
title_full_unstemmed	A genetic basis for the variation in the vulnerability of cancer to DNA damage
title_sort	genetic basis for the variation in the vulnerability of cancer to dna damage
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/877ae97e5e624e97832802165a437654
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A genetic basis for the variation in the vulnerability of cancer to DNA damage

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