Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections

Didem &Scedil;en Karaman,1 Ay&scedil;enur Pamukçu,2 M Baran Karakaplan,3 Ozden Kocaoglu,1 Jessica M Rosenholm4 1Biomedical Engineering Department, Faculty of Engineering and Architecture, &Idot;zmir Katip Çelebi University, &Idot;zmir, 35620, Turkey; 2&Idot;zmir Kâtip Çelebi Univ...

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Autores principales:	Şen Karaman D, Pamukçu A, Karakaplan MB, Kocaoglu O, Rosenholm JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mesoporous silica nanoparticles bacteria antibacterial bacterial separation biosensors biomedical imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/877b7ba9a6dd4faebbb2a43c5ad0cc31
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spelling	oai:doaj.org-article:877b7ba9a6dd4faebbb2a43c5ad0cc312021-12-02T17:18:06ZRecent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections1178-2013https://doaj.org/article/877b7ba9a6dd4faebbb2a43c5ad0cc312021-09-01T00:00:00Zhttps://www.dovepress.com/recent-advances-in-the-use-of-mesoporous-silica-nanoparticles-for-the--peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Didem &Scedil;en Karaman,1 Ay&scedil;enur Pamukçu,2 M Baran Karakaplan,3 Ozden Kocaoglu,1 Jessica M Rosenholm4 1Biomedical Engineering Department, Faculty of Engineering and Architecture, &Idot;zmir Katip Çelebi University, &Idot;zmir, 35620, Turkey; 2&Idot;zmir Kâtip Çelebi University, Graduate School of Natural and Applied Sciences, Department of Biomedical Technologies, &Idot;zmir, Turkey; 3&Idot;zmir Kâtip Çelebi University, Graduate School of Natural and Applied Sciences, Department of Biomedical Engineering, &Idot;zmir, Turkey; 4Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, 20520, FinlandCorrespondence: Didem &Scedil;en Karaman Email didem.sen.karaman@ikcu.edu.trAbstract: Public awareness of infectious diseases has increased in recent months, not only due to the current COVID-19 outbreak but also because of antimicrobial resistance (AMR) being declared a top-10 global health threat by the World Health Organization (WHO) in 2019. These global issues have spiked the realization that new and more efficient methods and approaches are urgently required to efficiently combat and overcome the failures in the diagnosis and therapy of infectious disease. This holds true not only for current diseases, but we should also have enough readiness to fight the unforeseen diseases so as to avoid future pandemics. A paradigm shift is needed, not only in infection treatment, but also diagnostic practices, to overcome the potential failures associated with early diagnosis stages, leading to unnecessary and inefficient treatments, while simultaneously promoting AMR. With the development of nanotechnology, nanomaterials fabricated as multifunctional nano-platforms for antibacterial therapeutics, diagnostics, or both (known as “theranostics”) have attracted increasing attention. In the research field of nanomedicine, mesoporous silica nanoparticles (MSN) with a tailored structure, large surface area, high loading capacity, abundant chemical versatility, and acceptable biocompatibility, have shown great potential to integrate the desired functions for diagnosis of bacterial infections. The focus of this review is to present the advances in mesoporous materials in the form of nanoparticles (NPs) or composites that can easily and flexibly accommodate dual or multifunctional capabilities of separation, identification and tracking performed during the diagnosis of infectious diseases together with the inspiring NP designs in diagnosis of bacterial infections.Keywords: mesoporous silica nanoparticles, bacteria, antibacterial, bacterial separation, biosensors, biomedical imaging, MSNŞen Karaman DPamukçu AKarakaplan MBKocaoglu ORosenholm JMDove Medical Pressarticlemesoporous silica nanoparticlesbacteriaantibacterialbacterial separationbiosensorsbiomedical imagingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6575-6591 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica nanoparticles bacteria antibacterial bacterial separation biosensors biomedical imaging Medicine (General) R5-920
spellingShingle	mesoporous silica nanoparticles bacteria antibacterial bacterial separation biosensors biomedical imaging Medicine (General) R5-920 Şen Karaman D Pamukçu A Karakaplan MB Kocaoglu O Rosenholm JM Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
description	Didem &Scedil;en Karaman,1 Ay&scedil;enur Pamukçu,2 M Baran Karakaplan,3 Ozden Kocaoglu,1 Jessica M Rosenholm4 1Biomedical Engineering Department, Faculty of Engineering and Architecture, &Idot;zmir Katip Çelebi University, &Idot;zmir, 35620, Turkey; 2&Idot;zmir Kâtip Çelebi University, Graduate School of Natural and Applied Sciences, Department of Biomedical Technologies, &Idot;zmir, Turkey; 3&Idot;zmir Kâtip Çelebi University, Graduate School of Natural and Applied Sciences, Department of Biomedical Engineering, &Idot;zmir, Turkey; 4Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, 20520, FinlandCorrespondence: Didem &Scedil;en Karaman Email didem.sen.karaman@ikcu.edu.trAbstract: Public awareness of infectious diseases has increased in recent months, not only due to the current COVID-19 outbreak but also because of antimicrobial resistance (AMR) being declared a top-10 global health threat by the World Health Organization (WHO) in 2019. These global issues have spiked the realization that new and more efficient methods and approaches are urgently required to efficiently combat and overcome the failures in the diagnosis and therapy of infectious disease. This holds true not only for current diseases, but we should also have enough readiness to fight the unforeseen diseases so as to avoid future pandemics. A paradigm shift is needed, not only in infection treatment, but also diagnostic practices, to overcome the potential failures associated with early diagnosis stages, leading to unnecessary and inefficient treatments, while simultaneously promoting AMR. With the development of nanotechnology, nanomaterials fabricated as multifunctional nano-platforms for antibacterial therapeutics, diagnostics, or both (known as “theranostics”) have attracted increasing attention. In the research field of nanomedicine, mesoporous silica nanoparticles (MSN) with a tailored structure, large surface area, high loading capacity, abundant chemical versatility, and acceptable biocompatibility, have shown great potential to integrate the desired functions for diagnosis of bacterial infections. The focus of this review is to present the advances in mesoporous materials in the form of nanoparticles (NPs) or composites that can easily and flexibly accommodate dual or multifunctional capabilities of separation, identification and tracking performed during the diagnosis of infectious diseases together with the inspiring NP designs in diagnosis of bacterial infections.Keywords: mesoporous silica nanoparticles, bacteria, antibacterial, bacterial separation, biosensors, biomedical imaging, MSN
format	article
author	Şen Karaman D Pamukçu A Karakaplan MB Kocaoglu O Rosenholm JM
author_facet	Şen Karaman D Pamukçu A Karakaplan MB Kocaoglu O Rosenholm JM
author_sort	Şen Karaman D
title	Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
title_short	Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
title_full	Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
title_fullStr	Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
title_full_unstemmed	Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
title_sort	recent advances in the use of mesoporous silica nanoparticles for the diagnosis of bacterial infections
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/877b7ba9a6dd4faebbb2a43c5ad0cc31
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Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections

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