An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data

The top challenges of adopting new methods to forensic DNA analysis in routine laboratories are often the capital investment and the expertise required to implement and validate such methods locally. In the case of next-generation sequencing, in the last decade, several specifically forensic commerc...

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Autores principales:	Tunde I. Huszar, Katherine B. Gettings, Peter M. Vallone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	massively parallel sequencing (MPS) next-generation sequencing (NGS) short tandem repeat (STR) sequence analysis software Genetics QH426-470
Acceso en línea:	https://doaj.org/article/877ba85cf49c4d01aae1a7fe2505058c
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spelling	oai:doaj.org-article:877ba85cf49c4d01aae1a7fe2505058c2021-11-25T17:41:24ZAn Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data10.3390/genes121117392073-4425https://doaj.org/article/877ba85cf49c4d01aae1a7fe2505058c2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1739https://doaj.org/toc/2073-4425The top challenges of adopting new methods to forensic DNA analysis in routine laboratories are often the capital investment and the expertise required to implement and validate such methods locally. In the case of next-generation sequencing, in the last decade, several specifically forensic commercial options became available, offering reliable and validated solutions. Despite this, the readily available expertise to analyze, interpret and understand such data is still perceived to be lagging behind. This review gives an introductory overview for the forensic scientists who are at the beginning of their journey with implementing next-generation sequencing locally and because most in the field do not have a bioinformatics background may find it difficult to navigate the new terms and analysis options available. The currently available open-source and commercial software for forensic sequencing data analysis are summarized here to provide an accessible starting point for those fairly new to the forensic application of massively parallel sequencing.Tunde I. HuszarKatherine B. GettingsPeter M. ValloneMDPI AGarticlemassively parallel sequencing (MPS)next-generation sequencing (NGS)short tandem repeat (STR)sequence analysissoftwareGeneticsQH426-470ENGenes, Vol 12, Iss 1739, p 1739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	massively parallel sequencing (MPS) next-generation sequencing (NGS) short tandem repeat (STR) sequence analysis software Genetics QH426-470
spellingShingle	massively parallel sequencing (MPS) next-generation sequencing (NGS) short tandem repeat (STR) sequence analysis software Genetics QH426-470 Tunde I. Huszar Katherine B. Gettings Peter M. Vallone An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
description	The top challenges of adopting new methods to forensic DNA analysis in routine laboratories are often the capital investment and the expertise required to implement and validate such methods locally. In the case of next-generation sequencing, in the last decade, several specifically forensic commercial options became available, offering reliable and validated solutions. Despite this, the readily available expertise to analyze, interpret and understand such data is still perceived to be lagging behind. This review gives an introductory overview for the forensic scientists who are at the beginning of their journey with implementing next-generation sequencing locally and because most in the field do not have a bioinformatics background may find it difficult to navigate the new terms and analysis options available. The currently available open-source and commercial software for forensic sequencing data analysis are summarized here to provide an accessible starting point for those fairly new to the forensic application of massively parallel sequencing.
format	article
author	Tunde I. Huszar Katherine B. Gettings Peter M. Vallone
author_facet	Tunde I. Huszar Katherine B. Gettings Peter M. Vallone
author_sort	Tunde I. Huszar
title	An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
title_short	An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
title_full	An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
title_fullStr	An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
title_full_unstemmed	An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
title_sort	introductory overview of open-source and commercial software options for the analysis of forensic sequencing data
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/877ba85cf49c4d01aae1a7fe2505058c
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An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data

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