Acute toxicity of nickel nanoparticles in rats after intravenous injection

Ruth R Magaye,1,* Xia Yue,1,* Baobo Zou,1 Hongbo Shi,1 Hongsheng Yu,2 Kui Liu,1 Xialu Lin,1 Jin Xu,1 Cui Yang,3 Aiguo Wu,3 Jinshun Zhao1 1Public Health Department, 2Affiliated Hospital of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo Unive...

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Autores principales:	Magaye RR, Yue X, Zou B, Shi H, Yu H, Liu K, Lin X, Xu J, Yang C, Wu A, Zhao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/877df93a117c4057a74dfc2ac3d76104
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spelling	oai:doaj.org-article:877df93a117c4057a74dfc2ac3d761042021-12-02T01:07:52ZAcute toxicity of nickel nanoparticles in rats after intravenous injection1178-2013https://doaj.org/article/877df93a117c4057a74dfc2ac3d761042014-03-01T00:00:00Zhttp://www.dovepress.com/acute-toxicity-of-nickel-nanoparticles-in-rats-after-intravenous-injec-a16092https://doaj.org/toc/1178-2013 Ruth R Magaye,1,* Xia Yue,1,* Baobo Zou,1 Hongbo Shi,1 Hongsheng Yu,2 Kui Liu,1 Xialu Lin,1 Jin Xu,1 Cui Yang,3 Aiguo Wu,3 Jinshun Zhao1 1Public Health Department, 2Affiliated Hospital of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, 3Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nano-devices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo, People's Republic of China *These authors contributed equally to this work Abstract: This study was carried out to add scientific data in regard to the use of metallic nanoparticles in nanomedicine. The acute toxicity of nickel (Ni) nanoparticles (50 nm), intravenously injected through the dorsal penile vein of Sprague Dawley rats was evaluated in this study. Fourteen days after injection, Ni nanoparticles induced liver and spleen injury, lung inflammation, and caused cardiac toxicity. These results indicate that precautionary measures should be taken with regard to the use of Ni nanoparticles or Ni compounds in nanomedicine. Keywords: nickel, nanoparticles, intravenous, acute toxicityMagaye RRYue XZou BShi HYu HLiu KLin XXu JYang CWu AZhao JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1393-1402 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Magaye RR Yue X Zou B Shi H Yu H Liu K Lin X Xu J Yang C Wu A Zhao J Acute toxicity of nickel nanoparticles in rats after intravenous injection
description	Ruth R Magaye,1,* Xia Yue,1,* Baobo Zou,1 Hongbo Shi,1 Hongsheng Yu,2 Kui Liu,1 Xialu Lin,1 Jin Xu,1 Cui Yang,3 Aiguo Wu,3 Jinshun Zhao1 1Public Health Department, 2Affiliated Hospital of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, 3Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nano-devices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo, People's Republic of China *These authors contributed equally to this work Abstract: This study was carried out to add scientific data in regard to the use of metallic nanoparticles in nanomedicine. The acute toxicity of nickel (Ni) nanoparticles (50 nm), intravenously injected through the dorsal penile vein of Sprague Dawley rats was evaluated in this study. Fourteen days after injection, Ni nanoparticles induced liver and spleen injury, lung inflammation, and caused cardiac toxicity. These results indicate that precautionary measures should be taken with regard to the use of Ni nanoparticles or Ni compounds in nanomedicine. Keywords: nickel, nanoparticles, intravenous, acute toxicity
format	article
author	Magaye RR Yue X Zou B Shi H Yu H Liu K Lin X Xu J Yang C Wu A Zhao J
author_facet	Magaye RR Yue X Zou B Shi H Yu H Liu K Lin X Xu J Yang C Wu A Zhao J
author_sort	Magaye RR
title	Acute toxicity of nickel nanoparticles in rats after intravenous injection
title_short	Acute toxicity of nickel nanoparticles in rats after intravenous injection
title_full	Acute toxicity of nickel nanoparticles in rats after intravenous injection
title_fullStr	Acute toxicity of nickel nanoparticles in rats after intravenous injection
title_full_unstemmed	Acute toxicity of nickel nanoparticles in rats after intravenous injection
title_sort	acute toxicity of nickel nanoparticles in rats after intravenous injection
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/877df93a117c4057a74dfc2ac3d76104
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Acute toxicity of nickel nanoparticles in rats after intravenous injection

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