High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Adherent-invasive E. coli (AIEC) are frequently isolated from Crohn’s disease (CD) patients. Here, Elhenawy et al. conduct a genome-wide screen to identify AIEC genes required for in vivo intestinal colonization, and show that a type IV secretion system contributes to AIEC persistence in the gut and...

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Autores principales:	Wael Elhenawy, Sarah Hordienko, Steven Gould, Alexander M. Oberc, Caressa N. Tsai, Troy P. Hubbard, Matthew K. Waldor, Brian K. Coombes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/877e302f916a4063a5156f75bd2209b5
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spelling	oai:doaj.org-article:877e302f916a4063a5156f75bd2209b52021-12-02T14:25:25ZHigh-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli10.1038/s41467-021-22306-w2041-1723https://doaj.org/article/877e302f916a4063a5156f75bd2209b52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22306-whttps://doaj.org/toc/2041-1723Adherent-invasive E. coli (AIEC) are frequently isolated from Crohn’s disease (CD) patients. Here, Elhenawy et al. conduct a genome-wide screen to identify AIEC genes required for in vivo intestinal colonization, and show that a type IV secretion system contributes to AIEC persistence in the gut and is enriched in CD patients’ isolates.Wael ElhenawySarah HordienkoSteven GouldAlexander M. ObercCaressa N. TsaiTroy P. HubbardMatthew K. WaldorBrian K. CoombesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wael Elhenawy Sarah Hordienko Steven Gould Alexander M. Oberc Caressa N. Tsai Troy P. Hubbard Matthew K. Waldor Brian K. Coombes High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
description	Adherent-invasive E. coli (AIEC) are frequently isolated from Crohn’s disease (CD) patients. Here, Elhenawy et al. conduct a genome-wide screen to identify AIEC genes required for in vivo intestinal colonization, and show that a type IV secretion system contributes to AIEC persistence in the gut and is enriched in CD patients’ isolates.
format	article
author	Wael Elhenawy Sarah Hordienko Steven Gould Alexander M. Oberc Caressa N. Tsai Troy P. Hubbard Matthew K. Waldor Brian K. Coombes
author_facet	Wael Elhenawy Sarah Hordienko Steven Gould Alexander M. Oberc Caressa N. Tsai Troy P. Hubbard Matthew K. Waldor Brian K. Coombes
author_sort	Wael Elhenawy
title	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
title_short	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
title_full	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
title_fullStr	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
title_full_unstemmed	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli
title_sort	high-throughput fitness screening and transcriptomics identify a role for a type iv secretion system in the pathogenesis of crohn’s disease-associated escherichia coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/877e302f916a4063a5156f75bd2209b5
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High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

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