An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement

Widya Istanto Nurcahyo,1 Anshoril Arifin,1 Aria Dian Primatika,1 Zainal Muttaqin,2 Cindy Elfira Boom,3 M Sofyan Harahap,1 Mochamat Mochamat,1 Taufik Eko Nugroho,1 Satrio Adi Wicaksono1 1Department of Anesthesiology and Intensive Care, Diponegoro University Faculty of Medicine/Dr. Kariadi General Hos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nurcahyo WI, Arifin A, Primatika AD, Muttaqin Z, Elfira Boom C, Harahap MS, Mochamat M, Eko Nugroho T, Wicaksono SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	c-reactive protein cardiac surgical procedure cognition disorders cognitive dysfunction heart valves postoperative complication Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/877fc597d0304fbbaded0c4dd7fc4336
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:877fc597d0304fbbaded0c4dd7fc4336
record_format	dspace
spelling	oai:doaj.org-article:877fc597d0304fbbaded0c4dd7fc43362021-11-18T19:40:26ZAn Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement1178-2048https://doaj.org/article/877fc597d0304fbbaded0c4dd7fc43362021-11-01T00:00:00Zhttps://www.dovepress.com/an-association-between-c-reactive-protein-levels-and-the-occurrence-of-peer-reviewed-fulltext-article-VHRMhttps://doaj.org/toc/1178-2048Widya Istanto Nurcahyo,1 Anshoril Arifin,1 Aria Dian Primatika,1 Zainal Muttaqin,2 Cindy Elfira Boom,3 M Sofyan Harahap,1 Mochamat Mochamat,1 Taufik Eko Nugroho,1 Satrio Adi Wicaksono1 1Department of Anesthesiology and Intensive Care, Diponegoro University Faculty of Medicine/Dr. Kariadi General Hospital, Semarang City, Central Java Province, Indonesia; 2Department of Neurosurgery, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Semarang City, Central Java Province, Indonesia; 3Department of Anesthesiology and Intensive Care, Cardiovascular Centre, Harapan Kita Hospital, Jakarta, IndonesiaCorrespondence: Widya Istanto NurcahyoDepartment of Anesthesiology and Intensive Care, Diponegoro University Faculty of Medicine/Dr. Kariadi General Hospital, Semarang City, Central Java Province, 50275, IndonesiaFax +62 2476928010Email widya_istanto2@yahoo.com; widya.istanto.dr@gmail.comBackground: Postoperative cognitive dysfunction (POCD) is defined as cognitive dysfunction related to inflammation after surgical procedures, which is common following cardiac surgery. Cognitive deficits are thought to result from a systemic inflammatory response. C-reactive protein (CRP) and other proinflammatory cytokines, which are released in response to inflammation, disrupt the blood–brain barrier and neurotransmission, resulting in POCD. This study aimed to determine the correlation between POCD and increased levels of CRP in patients who had undergone heart valve replacement.Methods: This study comprised 32 patients with normal cognitive function undergoing heart valve replacement. The CRP levels were measured before surgery and on the second postoperative day, and cognitive function was examined via the Indonesian-adapted Montreal Cognitive Assessment (MOCA-INA) on the third postoperative day. Data were analyzed using Spearman correlation test.Results: Of the 32 patients, 28 (87.5%) experienced POCD. The median level of CRP was 6.6 mg/dL (interquartile range: 4.0, 8.3 g/dL). According to Spearman correlation test, increased levels of CRP were significantly related to POCD following heart valve replacement (p = 0.003, r = 0.501). The receiver operating characteristic curve indicated that the CRP cutoff level was 3.345 mg/dL, and the sensitivity and specificity were 89.3% and 75%, respectively.Conclusion: High expression level of CRP was correlated with POCD following heart valve replacement.Keywords: C-reactive protein, cardiac surgical procedure, cognition disorders, cognitive dysfunction, heart valves, postoperative complicationNurcahyo WIArifin APrimatika ADMuttaqin ZElfira Boom CHarahap MSMochamat MEko Nugroho TWicaksono SADove Medical Pressarticlec-reactive proteincardiac surgical procedurecognition disorderscognitive dysfunctionheart valvespostoperative complicationDiseases of the circulatory (Cardiovascular) systemRC666-701ENVascular Health and Risk Management, Vol Volume 17, Pp 713-720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein cardiac surgical procedure cognition disorders cognitive dysfunction heart valves postoperative complication Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	c-reactive protein cardiac surgical procedure cognition disorders cognitive dysfunction heart valves postoperative complication Diseases of the circulatory (Cardiovascular) system RC666-701 Nurcahyo WI Arifin A Primatika AD Muttaqin Z Elfira Boom C Harahap MS Mochamat M Eko Nugroho T Wicaksono SA An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
description	Widya Istanto Nurcahyo,1 Anshoril Arifin,1 Aria Dian Primatika,1 Zainal Muttaqin,2 Cindy Elfira Boom,3 M Sofyan Harahap,1 Mochamat Mochamat,1 Taufik Eko Nugroho,1 Satrio Adi Wicaksono1 1Department of Anesthesiology and Intensive Care, Diponegoro University Faculty of Medicine/Dr. Kariadi General Hospital, Semarang City, Central Java Province, Indonesia; 2Department of Neurosurgery, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Semarang City, Central Java Province, Indonesia; 3Department of Anesthesiology and Intensive Care, Cardiovascular Centre, Harapan Kita Hospital, Jakarta, IndonesiaCorrespondence: Widya Istanto NurcahyoDepartment of Anesthesiology and Intensive Care, Diponegoro University Faculty of Medicine/Dr. Kariadi General Hospital, Semarang City, Central Java Province, 50275, IndonesiaFax +62 2476928010Email widya_istanto2@yahoo.com; widya.istanto.dr@gmail.comBackground: Postoperative cognitive dysfunction (POCD) is defined as cognitive dysfunction related to inflammation after surgical procedures, which is common following cardiac surgery. Cognitive deficits are thought to result from a systemic inflammatory response. C-reactive protein (CRP) and other proinflammatory cytokines, which are released in response to inflammation, disrupt the blood–brain barrier and neurotransmission, resulting in POCD. This study aimed to determine the correlation between POCD and increased levels of CRP in patients who had undergone heart valve replacement.Methods: This study comprised 32 patients with normal cognitive function undergoing heart valve replacement. The CRP levels were measured before surgery and on the second postoperative day, and cognitive function was examined via the Indonesian-adapted Montreal Cognitive Assessment (MOCA-INA) on the third postoperative day. Data were analyzed using Spearman correlation test.Results: Of the 32 patients, 28 (87.5%) experienced POCD. The median level of CRP was 6.6 mg/dL (interquartile range: 4.0, 8.3 g/dL). According to Spearman correlation test, increased levels of CRP were significantly related to POCD following heart valve replacement (p = 0.003, r = 0.501). The receiver operating characteristic curve indicated that the CRP cutoff level was 3.345 mg/dL, and the sensitivity and specificity were 89.3% and 75%, respectively.Conclusion: High expression level of CRP was correlated with POCD following heart valve replacement.Keywords: C-reactive protein, cardiac surgical procedure, cognition disorders, cognitive dysfunction, heart valves, postoperative complication
format	article
author	Nurcahyo WI Arifin A Primatika AD Muttaqin Z Elfira Boom C Harahap MS Mochamat M Eko Nugroho T Wicaksono SA
author_facet	Nurcahyo WI Arifin A Primatika AD Muttaqin Z Elfira Boom C Harahap MS Mochamat M Eko Nugroho T Wicaksono SA
author_sort	Nurcahyo WI
title	An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
title_short	An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
title_full	An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
title_fullStr	An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
title_full_unstemmed	An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement
title_sort	association between c-reactive protein levels and the occurrence of cognitive dysfunction after heart valve replacement
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/877fc597d0304fbbaded0c4dd7fc4336
work_keys_str_mv	AT nurcahyowi anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT arifina anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT primatikaad anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT muttaqinz anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT elfiraboomc anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT harahapms anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT mochamatm anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT ekonugrohot anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT wicaksonosa anassociationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT nurcahyowi associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT arifina associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT primatikaad associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT muttaqinz associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT elfiraboomc associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT harahapms associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT mochamatm associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT ekonugrohot associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement AT wicaksonosa associationbetweencreactiveproteinlevelsandtheoccurrenceofcognitivedysfunctionafterheartvalvereplacement
_version_	1718420738114846720

An Association Between C-Reactive Protein Levels and the Occurrence of Cognitive Dysfunction After Heart Valve Replacement

Ejemplares similares