DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

hNEIL1 (human endonuclease VIII-like 1) is a broadly specific DNA glycosylase for base excision repair. Here, the authors show that hNEIL1 can assume activated or triage conformations: the structural basis for the mechanism that enables broad specificity and reduces futile repair of normal bases.

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Autores principales:	Menghao Liu, Jun Zhang, Chenxu Zhu, Xiaoxue Zhang, Weide Xiao, Yongchang Yan, Lulu Liu, Hu Zeng, Yi Qin Gao, Chengqi Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8780602d86db4f4cb38fffdca4e6d341
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spelling	oai:doaj.org-article:8780602d86db4f4cb38fffdca4e6d3412021-12-02T18:33:59ZDNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes10.1038/s41467-021-24431-y2041-1723https://doaj.org/article/8780602d86db4f4cb38fffdca4e6d3412021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24431-yhttps://doaj.org/toc/2041-1723hNEIL1 (human endonuclease VIII-like 1) is a broadly specific DNA glycosylase for base excision repair. Here, the authors show that hNEIL1 can assume activated or triage conformations: the structural basis for the mechanism that enables broad specificity and reduces futile repair of normal bases.Menghao LiuJun ZhangChenxu ZhuXiaoxue ZhangWeide XiaoYongchang YanLulu LiuHu ZengYi Qin GaoChengqi YiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Menghao Liu Jun Zhang Chenxu Zhu Xiaoxue Zhang Weide Xiao Yongchang Yan Lulu Liu Hu Zeng Yi Qin Gao Chengqi Yi DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
description	hNEIL1 (human endonuclease VIII-like 1) is a broadly specific DNA glycosylase for base excision repair. Here, the authors show that hNEIL1 can assume activated or triage conformations: the structural basis for the mechanism that enables broad specificity and reduces futile repair of normal bases.
format	article
author	Menghao Liu Jun Zhang Chenxu Zhu Xiaoxue Zhang Weide Xiao Yongchang Yan Lulu Liu Hu Zeng Yi Qin Gao Chengqi Yi
author_facet	Menghao Liu Jun Zhang Chenxu Zhu Xiaoxue Zhang Weide Xiao Yongchang Yan Lulu Liu Hu Zeng Yi Qin Gao Chengqi Yi
author_sort	Menghao Liu
title	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
title_short	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
title_full	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
title_fullStr	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
title_full_unstemmed	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
title_sort	dna repair glycosylase hneil1 triages damaged bases via competing interaction modes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8780602d86db4f4cb38fffdca4e6d341
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DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

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