The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study

Lisanne Tap,1 Lisanne J Dommershuijsen,1 Andrea Corsonello,2 Fabrizia Lattanzio,2 Silvia Bustacchini,2 Gijsbertus Ziere,1 Jan LCM van Saase,3 Francesco US Mattace-Raso1 1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Ne...

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Autores principales:	Tap L, Dommershuijsen LJ, Corsonello A, Lattanzio F, Bustacchini S, Ziere G, van Saase JLCM, Mattace-Raso FUS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	arterial stiffness health-related quality of life eq-5d older persons Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/878219d5b4d84d75a5042f7a89015124
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spelling	oai:doaj.org-article:878219d5b4d84d75a5042f7a890151242021-12-02T10:56:59ZThe Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study1178-1998https://doaj.org/article/878219d5b4d84d75a5042f7a890151242020-02-01T00:00:00Zhttps://www.dovepress.com/the-possible-impact-of-aortic-stiffness-on-quality-of-late-life-an-exp-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Lisanne Tap,1 Lisanne J Dommershuijsen,1 Andrea Corsonello,2 Fabrizia Lattanzio,2 Silvia Bustacchini,2 Gijsbertus Ziere,1 Jan LCM van Saase,3 Francesco US Mattace-Raso1 1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; 2Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy; 3Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the NetherlandsCorrespondence: Francesco US Mattace-RasoSection Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Room Rg-527, PO BOX 2040, Rotterdam 3000 CA, the NetherlandsTel +31 10703 5979Fax +31 10703 47 68Email f.mattaceraso@erasmusmc.nlPurpose: Aortic stiffness (AS) is associated with cardiovascular events and all-cause mortality in the older population. AS might also influence the health-related quality of life (HRQOL) as a result of the negative effects of AS on cognitive and physical morbidity. We aimed to investigate the possible association between AS and HRQOL in people aged 75 years and over.Patients and Methods: This cross-sectional study was part of the SCOPE study, an international multicenter cohort observational study. The indicators for AS were aortic pulse wave velocity (aPWV) and central pulse pressure (cPP). HRQOL was assessed using the EQ-5D index and the EQ-5D visual analog scale (VAS). ANCOVA and multivariate regression models were used to investigate possible associations.Results: We included 280 Dutch participants of the SCOPE study. Median age was 79 years (IQR 76– 83) and 42.1% were women. Participants reporting any problem on the EQ-5D index (n=214) had higher values of aPWV (12.6 vs 12.2 m/s, p = 0.024) than participants not experiencing any problem (n=66) and comparable values of cPP (44.4 vs 42.0 mmHg, p = 0.119). Estimates only slightly changed after adjustments. No association was found between indicators of AS and EQ-5D VAS.Conclusion: Aortic stiffness was associated with impaired quality of late life. This association could be mediated by subclinical vascular pathology affecting mental and physical health.Keywords: arterial stiffness, health-related quality of life, EQ-5D, older personsTap LDommershuijsen LJCorsonello ALattanzio FBustacchini SZiere Gvan Saase JLCMMattace-Raso FUSDove Medical Pressarticlearterial stiffnesshealth-related quality of lifeeq-5dolder personsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 133-140 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial stiffness health-related quality of life eq-5d older persons Geriatrics RC952-954.6
spellingShingle	arterial stiffness health-related quality of life eq-5d older persons Geriatrics RC952-954.6 Tap L Dommershuijsen LJ Corsonello A Lattanzio F Bustacchini S Ziere G van Saase JLCM Mattace-Raso FUS The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
description	Lisanne Tap,1 Lisanne J Dommershuijsen,1 Andrea Corsonello,2 Fabrizia Lattanzio,2 Silvia Bustacchini,2 Gijsbertus Ziere,1 Jan LCM van Saase,3 Francesco US Mattace-Raso1 1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; 2Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy; 3Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the NetherlandsCorrespondence: Francesco US Mattace-RasoSection Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Room Rg-527, PO BOX 2040, Rotterdam 3000 CA, the NetherlandsTel +31 10703 5979Fax +31 10703 47 68Email f.mattaceraso@erasmusmc.nlPurpose: Aortic stiffness (AS) is associated with cardiovascular events and all-cause mortality in the older population. AS might also influence the health-related quality of life (HRQOL) as a result of the negative effects of AS on cognitive and physical morbidity. We aimed to investigate the possible association between AS and HRQOL in people aged 75 years and over.Patients and Methods: This cross-sectional study was part of the SCOPE study, an international multicenter cohort observational study. The indicators for AS were aortic pulse wave velocity (aPWV) and central pulse pressure (cPP). HRQOL was assessed using the EQ-5D index and the EQ-5D visual analog scale (VAS). ANCOVA and multivariate regression models were used to investigate possible associations.Results: We included 280 Dutch participants of the SCOPE study. Median age was 79 years (IQR 76– 83) and 42.1% were women. Participants reporting any problem on the EQ-5D index (n=214) had higher values of aPWV (12.6 vs 12.2 m/s, p = 0.024) than participants not experiencing any problem (n=66) and comparable values of cPP (44.4 vs 42.0 mmHg, p = 0.119). Estimates only slightly changed after adjustments. No association was found between indicators of AS and EQ-5D VAS.Conclusion: Aortic stiffness was associated with impaired quality of late life. This association could be mediated by subclinical vascular pathology affecting mental and physical health.Keywords: arterial stiffness, health-related quality of life, EQ-5D, older persons
format	article
author	Tap L Dommershuijsen LJ Corsonello A Lattanzio F Bustacchini S Ziere G van Saase JLCM Mattace-Raso FUS
author_facet	Tap L Dommershuijsen LJ Corsonello A Lattanzio F Bustacchini S Ziere G van Saase JLCM Mattace-Raso FUS
author_sort	Tap L
title	The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
title_short	The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
title_full	The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
title_fullStr	The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
title_full_unstemmed	The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study
title_sort	possible impact of aortic stiffness on quality of late life: an exploratory study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/878219d5b4d84d75a5042f7a89015124
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The Possible Impact of Aortic Stiffness on Quality of Late Life: An Exploratory Study

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