PrPC as a Transducer of Physiological and Pathological Signals

After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and disease. PrPC, which is located mainly at the pla...

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Autores principales:	Jessica D. Panes, Paulina Saavedra, Benjamin Pineda, Kathleen Escobar, Magdalena E. Cuevas, Gustavo Moraga-Cid, Jorge Fuentealba, Coralia I. Rivas, Human Rezaei, Carola Muñoz-Montesino
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PrP Aβ PrPC signaling PrPC role PrPC in CNS Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/87823bf2331544b9a228724798e160fa
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spelling	oai:doaj.org-article:87823bf2331544b9a228724798e160fa2021-11-30T09:58:07ZPrPC as a Transducer of Physiological and Pathological Signals1662-509910.3389/fnmol.2021.762918https://doaj.org/article/87823bf2331544b9a228724798e160fa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.762918/fullhttps://doaj.org/toc/1662-5099After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and disease. PrPC, which is located mainly at the plasma membrane of neuronal cells attached by a glycosylphosphatidylinositol (GPI) anchor, can act as a receptor or transducer from external signaling. Although the precise role of PrPC remains elusive, a variety of functions have been proposed for this protein, namely, neuronal excitability and viability. Although many issues must be solved to clearly define the role of PrPC, its connection to the central nervous system (CNS) and to several misfolding-associated diseases makes PrPC an interesting pharmacological target. In a physiological context, several reports have proposed that PrPC modulates synaptic transmission, interacting with various proteins, namely, ion pumps, channels, and metabotropic receptors. PrPC has also been implicated in the pathophysiological cell signaling induced by β-amyloid peptide that leads to synaptic dysfunction in the context of Alzheimer’s disease (AD), as a mediator of Aβ-induced cell toxicity. Additionally, it has been implicated in other proteinopathies as well. In this review, we aimed to analyze the role of PrPC as a transducer of physiological and pathological signaling.Jessica D. PanesPaulina SaavedraPaulina SaavedraBenjamin PinedaKathleen EscobarKathleen EscobarMagdalena E. CuevasGustavo Moraga-CidJorge FuentealbaCoralia I. RivasHuman RezaeiHuman RezaeiHuman RezaeiCarola Muñoz-MontesinoFrontiers Media S.A.articlePrPAβPrPC signalingPrPC rolePrPC in CNSAlzheimer’s diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PrP Aβ PrPC signaling PrPC role PrPC in CNS Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	PrP Aβ PrPC signaling PrPC role PrPC in CNS Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jessica D. Panes Paulina Saavedra Paulina Saavedra Benjamin Pineda Kathleen Escobar Kathleen Escobar Magdalena E. Cuevas Gustavo Moraga-Cid Jorge Fuentealba Coralia I. Rivas Human Rezaei Human Rezaei Human Rezaei Carola Muñoz-Montesino PrPC as a Transducer of Physiological and Pathological Signals
description	After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and disease. PrPC, which is located mainly at the plasma membrane of neuronal cells attached by a glycosylphosphatidylinositol (GPI) anchor, can act as a receptor or transducer from external signaling. Although the precise role of PrPC remains elusive, a variety of functions have been proposed for this protein, namely, neuronal excitability and viability. Although many issues must be solved to clearly define the role of PrPC, its connection to the central nervous system (CNS) and to several misfolding-associated diseases makes PrPC an interesting pharmacological target. In a physiological context, several reports have proposed that PrPC modulates synaptic transmission, interacting with various proteins, namely, ion pumps, channels, and metabotropic receptors. PrPC has also been implicated in the pathophysiological cell signaling induced by β-amyloid peptide that leads to synaptic dysfunction in the context of Alzheimer’s disease (AD), as a mediator of Aβ-induced cell toxicity. Additionally, it has been implicated in other proteinopathies as well. In this review, we aimed to analyze the role of PrPC as a transducer of physiological and pathological signaling.
format	article
author	Jessica D. Panes Paulina Saavedra Paulina Saavedra Benjamin Pineda Kathleen Escobar Kathleen Escobar Magdalena E. Cuevas Gustavo Moraga-Cid Jorge Fuentealba Coralia I. Rivas Human Rezaei Human Rezaei Human Rezaei Carola Muñoz-Montesino
author_facet	Jessica D. Panes Paulina Saavedra Paulina Saavedra Benjamin Pineda Kathleen Escobar Kathleen Escobar Magdalena E. Cuevas Gustavo Moraga-Cid Jorge Fuentealba Coralia I. Rivas Human Rezaei Human Rezaei Human Rezaei Carola Muñoz-Montesino
author_sort	Jessica D. Panes
title	PrPC as a Transducer of Physiological and Pathological Signals
title_short	PrPC as a Transducer of Physiological and Pathological Signals
title_full	PrPC as a Transducer of Physiological and Pathological Signals
title_fullStr	PrPC as a Transducer of Physiological and Pathological Signals
title_full_unstemmed	PrPC as a Transducer of Physiological and Pathological Signals
title_sort	prpc as a transducer of physiological and pathological signals
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/87823bf2331544b9a228724798e160fa
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PrPC as a Transducer of Physiological and Pathological Signals

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