In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

Abstract Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope u...

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Autores principales:	Jérémy Vizet, Jean Rehbinder, Stanislas Deby, Stéphane Roussel, André Nazac, Ranya Soufan, Catherine Genestie, Christine Haie-Meder, Hervé Fernandez, François Moreau, Angelo Pierangelo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87836426f3d942f49205f54c995472de
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spelling	oai:doaj.org-article:87836426f3d942f49205f54c995472de2021-12-02T11:52:30ZIn vivo imaging of uterine cervix with a Mueller polarimetric colposcope10.1038/s41598-017-02645-92045-2322https://doaj.org/article/87836426f3d942f49205f54c995472de2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02645-9https://doaj.org/toc/2045-2322Abstract Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the in vivo application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested in vivo on a number of patients in the field.Jérémy VizetJean RehbinderStanislas DebyStéphane RousselAndré NazacRanya SoufanCatherine GenestieChristine Haie-MederHervé FernandezFrançois MoreauAngelo PierangeloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jérémy Vizet Jean Rehbinder Stanislas Deby Stéphane Roussel André Nazac Ranya Soufan Catherine Genestie Christine Haie-Meder Hervé Fernandez François Moreau Angelo Pierangelo In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
description	Abstract Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the in vivo application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested in vivo on a number of patients in the field.
format	article
author	Jérémy Vizet Jean Rehbinder Stanislas Deby Stéphane Roussel André Nazac Ranya Soufan Catherine Genestie Christine Haie-Meder Hervé Fernandez François Moreau Angelo Pierangelo
author_facet	Jérémy Vizet Jean Rehbinder Stanislas Deby Stéphane Roussel André Nazac Ranya Soufan Catherine Genestie Christine Haie-Meder Hervé Fernandez François Moreau Angelo Pierangelo
author_sort	Jérémy Vizet
title	In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_short	In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_full	In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_fullStr	In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_full_unstemmed	In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_sort	in vivo imaging of uterine cervix with a mueller polarimetric colposcope
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87836426f3d942f49205f54c995472de
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In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

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