Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.

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Autores principales:	Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr, Manfred Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8783689044924d8ba5fdd958f3eeabd4
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spelling	oai:doaj.org-article:8783689044924d8ba5fdd958f3eeabd42021-12-02T18:00:09ZEngineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function10.1038/s41467-020-17970-32041-1723https://doaj.org/article/8783689044924d8ba5fdd958f3eeabd42020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17970-3https://doaj.org/toc/2041-1723The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.Benjamin SalzerChristina M. SchuellerCharlotte U. ZajcTimo PetersMichael A. SchoeberBoris KovacicMichelle C. BuriElisabeth LobnerOmer DushekJohannes B. HuppaChristian ObingerEva M. PutzWolfgang HolterMichael W. TraxlmayrManfred LehnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
description	The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.
format	article
author	Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner
author_facet	Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner
author_sort	Benjamin Salzer
title	Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
title_short	Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
title_full	Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
title_fullStr	Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
title_full_unstemmed	Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
title_sort	engineering avidcars for combinatorial antigen recognition and reversible control of car function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8783689044924d8ba5fdd958f3eeabd4
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Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

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