Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.

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Autores principales:	Pierrick Moreau, Axel Cournac, Gianna Aurora Palumbo, Martial Marbouty, Shogofa Mortaza, Agnes Thierry, Stefano Cairo, Marc Lavigne, Romain Koszul, Christine Neuveut
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/878cd31675d7462e94de500ad5635813
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spelling	oai:doaj.org-article:878cd31675d7462e94de500ad56358132021-12-02T16:49:31ZTridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin10.1038/s41467-018-06739-42041-1723https://doaj.org/article/878cd31675d7462e94de500ad56358132018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06739-4https://doaj.org/toc/2041-1723Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.Pierrick MoreauAxel CournacGianna Aurora PalumboMartial MarboutyShogofa MortazaAgnes ThierryStefano CairoMarc LavigneRomain KoszulChristine NeuveutNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
description	Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.
format	article
author	Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut
author_facet	Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut
author_sort	Pierrick Moreau
title	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_short	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_full	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_fullStr	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_full_unstemmed	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_sort	tridimensional infiltration of dna viruses into the host genome shows preferential contact with active chromatin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/878cd31675d7462e94de500ad5635813
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Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

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