Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease

Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the central nervous system. Early treatment for PD is efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery to...

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Autores principales:	Victoria Monge-Fuentes, Andréia Biolchi Mayer, Marcos Robalinho Lima, Luiza Ribeiro Geraldes, Larissa Nepomuceno Zanotto, Karla Graziella Moreira, Olimpia Paschoal Martins, Henrique Luís Piva, Maria Sueli Soares Felipe, Andre Correa Amaral, Anamélia Lorenzetti Bocca, Antonio Claudio Tedesco, Márcia Renata Mortari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/878f8f5c6a6f4583aee909721c20dc25
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spelling	oai:doaj.org-article:878f8f5c6a6f4583aee909721c20dc252021-12-02T16:24:56ZDopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease10.1038/s41598-021-94175-82045-2322https://doaj.org/article/878f8f5c6a6f4583aee909721c20dc252021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94175-8https://doaj.org/toc/2045-2322Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the central nervous system. Early treatment for PD is efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery to the brain using smaller dosages, while crossing the complex brain-blood barrier (BBB), are highly desirable to ensure treatment efficacy and decrease/avoid unwanted outcomes. Our goal was to design and test the neurotherapeutic potential of a forefront nanoparticle-based technology composed of albumin/PLGA nanosystems loaded with dopamine (ALNP-DA) in 6-OHDA PD mice model. ALNP-DA effectively crossed the BBB, replenishing dopamine at the nigrostriatal pathway, resulting in significant motor symptom improvement when compared to Lesioned and L-DOPA groups. Notably, ALNP-DA (20 mg/animal dose) additionally up-regulated and restored motor coordination, balance, and sensorimotor performance to non-lesioned (Sham) animal level. Overall, ALNPs represent an innovative, non-invasive nano-therapeutical strategy for PD, considering its efficacy to circumvent the BBB and ultimately deliver the drug of interest to the brain.Victoria Monge-FuentesAndréia Biolchi MayerMarcos Robalinho LimaLuiza Ribeiro GeraldesLarissa Nepomuceno ZanottoKarla Graziella MoreiraOlimpia Paschoal MartinsHenrique Luís PivaMaria Sueli Soares FelipeAndre Correa AmaralAnamélia Lorenzetti BoccaAntonio Claudio TedescoMárcia Renata MortariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Victoria Monge-Fuentes Andréia Biolchi Mayer Marcos Robalinho Lima Luiza Ribeiro Geraldes Larissa Nepomuceno Zanotto Karla Graziella Moreira Olimpia Paschoal Martins Henrique Luís Piva Maria Sueli Soares Felipe Andre Correa Amaral Anamélia Lorenzetti Bocca Antonio Claudio Tedesco Márcia Renata Mortari Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
description	Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the central nervous system. Early treatment for PD is efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery to the brain using smaller dosages, while crossing the complex brain-blood barrier (BBB), are highly desirable to ensure treatment efficacy and decrease/avoid unwanted outcomes. Our goal was to design and test the neurotherapeutic potential of a forefront nanoparticle-based technology composed of albumin/PLGA nanosystems loaded with dopamine (ALNP-DA) in 6-OHDA PD mice model. ALNP-DA effectively crossed the BBB, replenishing dopamine at the nigrostriatal pathway, resulting in significant motor symptom improvement when compared to Lesioned and L-DOPA groups. Notably, ALNP-DA (20 mg/animal dose) additionally up-regulated and restored motor coordination, balance, and sensorimotor performance to non-lesioned (Sham) animal level. Overall, ALNPs represent an innovative, non-invasive nano-therapeutical strategy for PD, considering its efficacy to circumvent the BBB and ultimately deliver the drug of interest to the brain.
format	article
author	Victoria Monge-Fuentes Andréia Biolchi Mayer Marcos Robalinho Lima Luiza Ribeiro Geraldes Larissa Nepomuceno Zanotto Karla Graziella Moreira Olimpia Paschoal Martins Henrique Luís Piva Maria Sueli Soares Felipe Andre Correa Amaral Anamélia Lorenzetti Bocca Antonio Claudio Tedesco Márcia Renata Mortari
author_facet	Victoria Monge-Fuentes Andréia Biolchi Mayer Marcos Robalinho Lima Luiza Ribeiro Geraldes Larissa Nepomuceno Zanotto Karla Graziella Moreira Olimpia Paschoal Martins Henrique Luís Piva Maria Sueli Soares Felipe Andre Correa Amaral Anamélia Lorenzetti Bocca Antonio Claudio Tedesco Márcia Renata Mortari
author_sort	Victoria Monge-Fuentes
title	Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
title_short	Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
title_full	Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
title_fullStr	Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
title_full_unstemmed	Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
title_sort	dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/878f8f5c6a6f4583aee909721c20dc25
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Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease

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