Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents
Abstract Polymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these gen...
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Nature Portfolio
2021
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oai:doaj.org-article:879346c293a549a2b8ace375c4aca3552021-12-02T17:52:23ZContribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents10.1038/s41598-021-91530-72045-2322https://doaj.org/article/879346c293a549a2b8ace375c4aca3552021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91530-7https://doaj.org/toc/2045-2322Abstract Polymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and their SNPs with vitamin B12 levels; (c) determine a polygenic risk score (PRS) using significant variants. This cross-sectional study included 168 children and adolescents, aged 9–13 years old. Total cobalamin was measured in plasma. Genotyping arrays and whole exome data were combined to yield ~ 7000 SNPs in 90 genes related to vitamin B12. The Efficient Local Ancestry Inference was used to estimate local ancestry for African (AFR), Native American, and European (EUR). The association between the genotypes and vitamin B12 levels were determined with generalized estimating equation. Vitamin B12 levels were driven by positive (EUR) and negative (AFR, AMR) correlations with genetic ancestry. A set of 36 variants were used to create a PRS that explained 42% of vitamin level variation. Vitamin B12 levels are influenced by genetic ancestry and a PRS explained almost 50% of the variation in plasma cobalamin in Brazilian children and adolescents.Carlos Alessandro FuzoFábio da Veiga UedSofia MocoOrnella CominettiSylviane MétaironSolenn PruvostAline CharpagneJerome CarayolRaul TorrieriWilson Araujo SilvaPatrick DescombesJim KaputJacqueline Pontes MonteiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
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Medicine R Science Q Carlos Alessandro Fuzo Fábio da Veiga Ued Sofia Moco Ornella Cominetti Sylviane Métairon Solenn Pruvost Aline Charpagne Jerome Carayol Raul Torrieri Wilson Araujo Silva Patrick Descombes Jim Kaput Jacqueline Pontes Monteiro Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| description |
Abstract Polymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and their SNPs with vitamin B12 levels; (c) determine a polygenic risk score (PRS) using significant variants. This cross-sectional study included 168 children and adolescents, aged 9–13 years old. Total cobalamin was measured in plasma. Genotyping arrays and whole exome data were combined to yield ~ 7000 SNPs in 90 genes related to vitamin B12. The Efficient Local Ancestry Inference was used to estimate local ancestry for African (AFR), Native American, and European (EUR). The association between the genotypes and vitamin B12 levels were determined with generalized estimating equation. Vitamin B12 levels were driven by positive (EUR) and negative (AFR, AMR) correlations with genetic ancestry. A set of 36 variants were used to create a PRS that explained 42% of vitamin level variation. Vitamin B12 levels are influenced by genetic ancestry and a PRS explained almost 50% of the variation in plasma cobalamin in Brazilian children and adolescents. |
| format |
article |
| author |
Carlos Alessandro Fuzo Fábio da Veiga Ued Sofia Moco Ornella Cominetti Sylviane Métairon Solenn Pruvost Aline Charpagne Jerome Carayol Raul Torrieri Wilson Araujo Silva Patrick Descombes Jim Kaput Jacqueline Pontes Monteiro |
| author_facet |
Carlos Alessandro Fuzo Fábio da Veiga Ued Sofia Moco Ornella Cominetti Sylviane Métairon Solenn Pruvost Aline Charpagne Jerome Carayol Raul Torrieri Wilson Araujo Silva Patrick Descombes Jim Kaput Jacqueline Pontes Monteiro |
| author_sort |
Carlos Alessandro Fuzo |
| title |
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| title_short |
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| title_full |
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| title_fullStr |
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| title_full_unstemmed |
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents |
| title_sort |
contribution of genetic ancestry and polygenic risk score in meeting vitamin b12 needs in healthy brazilian children and adolescents |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/879346c293a549a2b8ace375c4aca355 |
| work_keys_str_mv |
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