Connecting genetic risk to disease end points through the human blood plasma proteome

Connecting genetic risk to disease end points through the human blood plasma proteome

Individual genetic variation can affect the levels of protein in blood, but detailed data sets linking these two types of data are rare. Here, the authors carry out a genome-wide association study of levels of over a thousand different proteins, and describe many new SNP-protein interactions.

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Detalles Bibliográficos
Autores principales: Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J. Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook-Kanamori, Eman K. Al-Dous, Yasmin A. Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert, Annette Peters, Gabi Kastenmüller, Christian Gieger, Johannes Graumann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8795d9d74e404676970c345596c0741f
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Descripción
Sumario:Individual genetic variation can affect the levels of protein in blood, but detailed data sets linking these two types of data are rare. Here, the authors carry out a genome-wide association study of levels of over a thousand different proteins, and describe many new SNP-protein interactions.

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