TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3

Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes fr...

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Autores principales:	John P. Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu, Jianke Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87a04eb49a6d4286879173b72990596b
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spelling	oai:doaj.org-article:87a04eb49a6d4286879173b72990596b2021-12-02T14:39:40ZTRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK310.1038/s41467-019-08584-52041-1723https://doaj.org/article/87a04eb49a6d4286879173b72990596b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08584-5https://doaj.org/toc/2041-1723Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes from TNF-induced apoptosis.John P. DowlingMohamed AlsabbaghChristina Del CasaleZheng-Gang LiuJianke ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
description	Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes from TNF-induced apoptosis.
format	article
author	John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang
author_facet	John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang
author_sort	John P. Dowling
title	TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
title_short	TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
title_full	TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
title_fullStr	TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
title_full_unstemmed	TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
title_sort	tradd regulates perinatal development and adulthood survival in mice lacking ripk1 and ripk3
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/87a04eb49a6d4286879173b72990596b
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TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3

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