Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

Jingjing Fu,1,2,* Junwei Gao,2,* Linji Gong,3,4 Yuanyuan Ma,1 Haiwei Xu,5 Zhanjun Gu,3,4 Jingci Zhu,1 Xiaotang Fan2 1School of Nursing, Third Military Medical University, Chongqing 400038, China; 2Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University,...

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Autores principales:	Fu J, Gao J, Gong L, Ma Y, Xu H, Gu Z, Zhu J, Fan X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Silica nanoparticles Nanotoxicity Hippocampal neurogenesis Neuroinflammation Social behavior Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/87a72571fa8e4faea24b3d4d197624db
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spelling	oai:doaj.org-article:87a72571fa8e4faea24b3d4d197624db2021-12-02T07:58:54ZSilica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life1178-2013https://doaj.org/article/87a72571fa8e4faea24b3d4d197624db2018-06-01T00:00:00Zhttps://www.dovepress.com/silica-nanoparticle-exposure-during-the-neonatal-period-impairs-hippoc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jingjing Fu,1,2,* Junwei Gao,2,* Linji Gong,3,4 Yuanyuan Ma,1 Haiwei Xu,5 Zhanjun Gu,3,4 Jingci Zhu,1 Xiaotang Fan2 1School of Nursing, Third Military Medical University, Chongqing 400038, China; 2Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing 400038, China; 3Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; 4University of Chinese Academy of Sciences, Beijing 100049, China; 5Southwest Eye Hospital/Southwest Hospital, Third Military Medical University, Chongqing 400038, China *These authors contributed equally to this work Introduction: Silica nanoparticles (SiO2-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period.Materials and methods: Herein, we investigated the effects of SiO2-NPs (doses of 10, 20, or 50 mg with a particle size of ~91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m3, respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults.Results: SiO2-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the hippocampal dentate gyrus (DG), and decreased hippocampal precursor proliferation in the DG-subgranular zone at P8. Moreover, after exposure to 20 mg of SiO2-NPs, mice exhibited social interaction deficits and slight anxiety-like behaviors in adulthood, but this exposure did not induce locomotor activity impairment, depression-like behavior, or short-term memory impairment.Discussion: These findings suggest that early-age SiO2-NP exposure induced inflammation and inhibited precursor proliferation in the DG in a dose-dependent manner, which might be related to the social dysfunction observed in adulthood. Keywords: silica nanoparticles, nanotoxicity, hippocampal neurogenesis, neuroinflammation, social behaviorFu JGao JGong LMa YXu HGu ZZhu JFan XDove Medical PressarticleSilica nanoparticlesNanotoxicityHippocampal neurogenesisNeuroinflammationSocial behaviorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3593-3608 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silica nanoparticles Nanotoxicity Hippocampal neurogenesis Neuroinflammation Social behavior Medicine (General) R5-920
spellingShingle	Silica nanoparticles Nanotoxicity Hippocampal neurogenesis Neuroinflammation Social behavior Medicine (General) R5-920 Fu J Gao J Gong L Ma Y Xu H Gu Z Zhu J Fan X Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
description	Jingjing Fu,1,2,* Junwei Gao,2,* Linji Gong,3,4 Yuanyuan Ma,1 Haiwei Xu,5 Zhanjun Gu,3,4 Jingci Zhu,1 Xiaotang Fan2 1School of Nursing, Third Military Medical University, Chongqing 400038, China; 2Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing 400038, China; 3Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; 4University of Chinese Academy of Sciences, Beijing 100049, China; 5Southwest Eye Hospital/Southwest Hospital, Third Military Medical University, Chongqing 400038, China *These authors contributed equally to this work Introduction: Silica nanoparticles (SiO2-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period.Materials and methods: Herein, we investigated the effects of SiO2-NPs (doses of 10, 20, or 50 mg with a particle size of ~91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m3, respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults.Results: SiO2-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the hippocampal dentate gyrus (DG), and decreased hippocampal precursor proliferation in the DG-subgranular zone at P8. Moreover, after exposure to 20 mg of SiO2-NPs, mice exhibited social interaction deficits and slight anxiety-like behaviors in adulthood, but this exposure did not induce locomotor activity impairment, depression-like behavior, or short-term memory impairment.Discussion: These findings suggest that early-age SiO2-NP exposure induced inflammation and inhibited precursor proliferation in the DG in a dose-dependent manner, which might be related to the social dysfunction observed in adulthood. Keywords: silica nanoparticles, nanotoxicity, hippocampal neurogenesis, neuroinflammation, social behavior
format	article
author	Fu J Gao J Gong L Ma Y Xu H Gu Z Zhu J Fan X
author_facet	Fu J Gao J Gong L Ma Y Xu H Gu Z Zhu J Fan X
author_sort	Fu J
title	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
title_short	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
title_full	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
title_fullStr	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
title_full_unstemmed	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
title_sort	silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/87a72571fa8e4faea24b3d4d197624db
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Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

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