A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS

Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive pati...

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Autores principales:	Shehar Bano Imran, Shabnam Dildar, Sadia Taj, Afshan Khanum, Qasim Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	high-sensitivity c-reactive protein diabetes mellitus hba1c Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/87a7e8f9da13447b92a5904750a29e8e
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spelling	oai:doaj.org-article:87a7e8f9da13447b92a5904750a29e8e2021-11-18T06:53:35ZA COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS0030-96482411-8842https://doaj.org/article/87a7e8f9da13447b92a5904750a29e8e2021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/4918/3594https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed. Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol. Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP.Shehar Bano ImranShabnam DildarSadia TajAfshan KhanumQasim AhmedArmy Medical College Rawalpindiarticlehigh-sensitivity c-reactive proteindiabetes mellitushba1cMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1651-1655 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-sensitivity c-reactive protein diabetes mellitus hba1c Medicine R Medicine (General) R5-920
spellingShingle	high-sensitivity c-reactive protein diabetes mellitus hba1c Medicine R Medicine (General) R5-920 Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
description	Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed. Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol. Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP.
format	article
author	Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed
author_facet	Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed
author_sort	Shehar Bano Imran
title	A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
title_short	A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
title_full	A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
title_fullStr	A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
title_full_unstemmed	A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
title_sort	comparative study of high sensitivity c-reactive protein (hs-crp) and glycemic markers in type 2 diabetes mellitus
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/87a7e8f9da13447b92a5904750a29e8e
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A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS

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