MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS

An important parameter of immunotropic preparation effect is the influence on the production of cytokines that provide the interaction between the effectors of both congenital and adaptive immunity. Cytokine level was determined in the work while using the methods of mucosal immunization with Immuno...

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Autores principales:	N. K. Akhmatova, O. V. Lebedinskaya, M. B. Brodovsky, E. A. Akhmatov, E. A. Lebedinskaya, E. A. Ilinykh, E. A. Kurbatova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	cytokines immunovac vp-4 mucosal methods of immunization Science Q
Acceso en línea:	https://doaj.org/article/87a9b15119104589b1820806980110da
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spelling	oai:doaj.org-article:87a9b15119104589b1820806980110da2021-11-23T06:14:19ZMICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS2541-94202587-9596https://doaj.org/article/87a9b15119104589b1820806980110da2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/928https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596An important parameter of immunotropic preparation effect is the influence on the production of cytokines that provide the interaction between the effectors of both congenital and adaptive immunity. Cytokine level was determined in the work while using the methods of mucosal immunization with Immunovac-VP-4 and compared with the subcutaneous introduction of this preparation. In case of intranasal and peroral methods of antigen application IL-5, IL-6, and IL-12 expression was found to be elevated, the same was true for IL-1β, IL-5, IL-6, IL-12, and IFN-γ under the subcutaneous immunization. Resulting mice cytokine profile confirmed that irrespective of the method of Immunovac introduction, the activation of immune effectors occurred that was manifested in the increase in proinflammatory and regulatory cytokine levels. It was concluded that the introduction of opportunistic microbial antigens initiated the activation of the cascade of immunologic reactions and under the influence of synthesized cytokines the polarization of immune response was involved that was predominantly of Th1 type.N. K. AkhmatovaO. V. LebedinskayaM. B. BrodovskyE. A. AkhmatovE. A. LebedinskayaE. A. IlinykhE. A. KurbatovaScientific Сentre for Family Health and Human Reproduction Problemsarticlecytokinesimmunovac vp-4mucosal methods of immunizationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 253-256 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines immunovac vp-4 mucosal methods of immunization Science Q
spellingShingle	cytokines immunovac vp-4 mucosal methods of immunization Science Q N. K. Akhmatova O. V. Lebedinskaya M. B. Brodovsky E. A. Akhmatov E. A. Lebedinskaya E. A. Ilinykh E. A. Kurbatova MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
description	An important parameter of immunotropic preparation effect is the influence on the production of cytokines that provide the interaction between the effectors of both congenital and adaptive immunity. Cytokine level was determined in the work while using the methods of mucosal immunization with Immunovac-VP-4 and compared with the subcutaneous introduction of this preparation. In case of intranasal and peroral methods of antigen application IL-5, IL-6, and IL-12 expression was found to be elevated, the same was true for IL-1β, IL-5, IL-6, IL-12, and IFN-γ under the subcutaneous immunization. Resulting mice cytokine profile confirmed that irrespective of the method of Immunovac introduction, the activation of immune effectors occurred that was manifested in the increase in proinflammatory and regulatory cytokine levels. It was concluded that the introduction of opportunistic microbial antigens initiated the activation of the cascade of immunologic reactions and under the influence of synthesized cytokines the polarization of immune response was involved that was predominantly of Th1 type.
format	article
author	N. K. Akhmatova O. V. Lebedinskaya M. B. Brodovsky E. A. Akhmatov E. A. Lebedinskaya E. A. Ilinykh E. A. Kurbatova
author_facet	N. K. Akhmatova O. V. Lebedinskaya M. B. Brodovsky E. A. Akhmatov E. A. Lebedinskaya E. A. Ilinykh E. A. Kurbatova
author_sort	N. K. Akhmatova
title	MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
title_short	MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
title_full	MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
title_fullStr	MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
title_full_unstemmed	MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS
title_sort	mice serum cytokine level under mucosal immunization with opportunistic microbial antigens
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/87a9b15119104589b1820806980110da
work_keys_str_mv	AT nkakhmatova miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT ovlebedinskaya miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT mbbrodovsky miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT eaakhmatov miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT ealebedinskaya miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT eailinykh miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens AT eakurbatova miceserumcytokinelevelundermucosalimmunizationwithopportunisticmicrobialantigens
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MICE SERUM CYTOKINE LEVEL UNDER MUCOSAL IMMUNIZATION WITH OPPORTUNISTIC MICROBIAL ANTIGENS

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