Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis

Purpose. Herbal medicine is one of crucial symbols of Chinese national medicine. Investigation on molecular responses of different herbal strategies against viral myocarditis is immeasurably conducive to targeting drug development in the current international absence of miracle treatment. Methods. L...

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Autores principales:	Yu Cao, Yang Liu, Tian Zhang, Jing Pan, Wei Lei, Boli Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi - Cambridge University Press 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/87a9db130c534247bf224caa3bca00c7
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spelling	oai:doaj.org-article:87a9db130c534247bf224caa3bca00c72021-12-02T19:24:16ZComparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis0016-67231469-507310.1155/2021/9952620https://doaj.org/article/87a9db130c534247bf224caa3bca00c72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9952620https://doaj.org/toc/0016-6723https://doaj.org/toc/1469-5073Purpose. Herbal medicine is one of crucial symbols of Chinese national medicine. Investigation on molecular responses of different herbal strategies against viral myocarditis is immeasurably conducive to targeting drug development in the current international absence of miracle treatment. Methods. Literature retrieval platforms were applied in the collection of existing empirical evidences for viral myocarditis-related single-herbal strategies. SwissTargetPrediction, Metascape, and Discovery Studio coordinating with multidatabases investigated underlying target genes, interactive proteins, and docking molecules in turn. Results. Six single-herbal medicines consisting of Huangqi (Hedysarum Multijugum Maxim), Yuganzi (Phyllanthi Fructus), Kushen (Sophorae Flavescentis Radix), Jianghuang (Curcumaelongae Rhizoma), Chaihu (Radix Bupleuri), and Jixueteng (Spatholobus Suberectus Dunn) meet the requirement. There were 11 overlapped and 73 unique natural components detected in these herbs. SLC6A2, SLC6A4, NOS2, PPARA, PPARG, ACHE, CYP2C19, CYP51A1, and CHRM2 were equally targeted by six herbs and identified as viral myocarditis-associated symbols. MCODE algorithm exposed the hub role of SRC and EGFR in strategies without Jianghuang. Subsequently, we learned intermolecular interactions of herbal components and their targeting heart-tissue-specific CHRM2, FABP3, TNNC1, TNNI3, TNNT2, and SCN5A and cardiac-myocytes-specific IL6, MMP1, and PLAT coupled with viral myocarditis. Ten interactive characteristics such as π-alkyl and van der Waals were modeled in which ARG111, LYS253, ILE114, and VAL11 on cardiac troponin (TNNC1-TNNI3-TNNT2) and ARG208, ASN106, and ALA258 on MMP1 fulfilled potential communicating anchor with ellagic acid, 5α, 9α-dihydroxymatrine, and leachianone g via hydrogen bond and hydrophobic interaction, respectively. Conclusions. The comprehensive outcomes uncover differences and linkages between six herbs against viral myocarditis through component and target analysis, fostering development of drugs.Yu CaoYang LiuTian ZhangJing PanWei LeiBoli ZhangHindawi - Cambridge University PressarticleGeneticsQH426-470ENGenetics Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Yu Cao Yang Liu Tian Zhang Jing Pan Wei Lei Boli Zhang Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
description	Purpose. Herbal medicine is one of crucial symbols of Chinese national medicine. Investigation on molecular responses of different herbal strategies against viral myocarditis is immeasurably conducive to targeting drug development in the current international absence of miracle treatment. Methods. Literature retrieval platforms were applied in the collection of existing empirical evidences for viral myocarditis-related single-herbal strategies. SwissTargetPrediction, Metascape, and Discovery Studio coordinating with multidatabases investigated underlying target genes, interactive proteins, and docking molecules in turn. Results. Six single-herbal medicines consisting of Huangqi (Hedysarum Multijugum Maxim), Yuganzi (Phyllanthi Fructus), Kushen (Sophorae Flavescentis Radix), Jianghuang (Curcumaelongae Rhizoma), Chaihu (Radix Bupleuri), and Jixueteng (Spatholobus Suberectus Dunn) meet the requirement. There were 11 overlapped and 73 unique natural components detected in these herbs. SLC6A2, SLC6A4, NOS2, PPARA, PPARG, ACHE, CYP2C19, CYP51A1, and CHRM2 were equally targeted by six herbs and identified as viral myocarditis-associated symbols. MCODE algorithm exposed the hub role of SRC and EGFR in strategies without Jianghuang. Subsequently, we learned intermolecular interactions of herbal components and their targeting heart-tissue-specific CHRM2, FABP3, TNNC1, TNNI3, TNNT2, and SCN5A and cardiac-myocytes-specific IL6, MMP1, and PLAT coupled with viral myocarditis. Ten interactive characteristics such as π-alkyl and van der Waals were modeled in which ARG111, LYS253, ILE114, and VAL11 on cardiac troponin (TNNC1-TNNI3-TNNT2) and ARG208, ASN106, and ALA258 on MMP1 fulfilled potential communicating anchor with ellagic acid, 5α, 9α-dihydroxymatrine, and leachianone g via hydrogen bond and hydrophobic interaction, respectively. Conclusions. The comprehensive outcomes uncover differences and linkages between six herbs against viral myocarditis through component and target analysis, fostering development of drugs.
format	article
author	Yu Cao Yang Liu Tian Zhang Jing Pan Wei Lei Boli Zhang
author_facet	Yu Cao Yang Liu Tian Zhang Jing Pan Wei Lei Boli Zhang
author_sort	Yu Cao
title	Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
title_short	Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
title_full	Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
title_fullStr	Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
title_full_unstemmed	Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis
title_sort	comparison and analysis on the existing single-herbal strategies against viral myocarditis
publisher	Hindawi - Cambridge University Press
publishDate	2021
url	https://doaj.org/article/87a9db130c534247bf224caa3bca00c7
work_keys_str_mv	AT yucao comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis AT yangliu comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis AT tianzhang comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis AT jingpan comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis AT weilei comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis AT bolizhang comparisonandanalysisontheexistingsingleherbalstrategiesagainstviralmyocarditis
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Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis

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