Gender-Specific Metabolomics Approach to Kidney Cancer

Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific <sup>1</su...

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Autores principales:	Stanisław Deja, Adam Litarski, Karolina Anna Mielko, Natalia Pudełko-Malik, Wojciech Wojtowicz, Adam Zabek, Tomasz Szydełko, Piotr Młynarz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	renal cell carcinoma RCC metabolomics serum NMR gender Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/87acef478051402aae3c68d39686ab82
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id	oai:doaj.org-article:87acef478051402aae3c68d39686ab82
record_format	dspace
spelling	oai:doaj.org-article:87acef478051402aae3c68d39686ab822021-11-25T18:20:46ZGender-Specific Metabolomics Approach to Kidney Cancer10.3390/metabo111107672218-1989https://doaj.org/article/87acef478051402aae3c68d39686ab822021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/767https://doaj.org/toc/2218-1989Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific <sup>1</sup>H NMR serum metabolic profiles of RCC patients and their matched controls. A number of differential metabolites were shared by male and female RCC patients. These RCC specific changes included lower lactate, threonine, histidine, and choline levels together with increased levels of pyruvate, <i>N</i>-acetylated glycoproteins, beta-hydroxybutyrate, acetoacetate, and lysine. Additionally, serum lactate/pyruvate ratio was a strong predictor of RCC status regardless of gender. Although only moderate changes in metabolic profiles were observed between control males and females there were substantial gender related differences among RCC patients. Gender specific metabolic features associated with RCC status were identified suggesting that different metabolic panels could be leveraged for a more precise diagnostic.Stanisław DejaAdam LitarskiKarolina Anna MielkoNatalia Pudełko-MalikWojciech WojtowiczAdam ZabekTomasz SzydełkoPiotr MłynarzMDPI AGarticlerenal cell carcinomaRCCmetabolomicsserumNMRgenderMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 767, p 767 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal cell carcinoma RCC metabolomics serum NMR gender Microbiology QR1-502
spellingShingle	renal cell carcinoma RCC metabolomics serum NMR gender Microbiology QR1-502 Stanisław Deja Adam Litarski Karolina Anna Mielko Natalia Pudełko-Malik Wojciech Wojtowicz Adam Zabek Tomasz Szydełko Piotr Młynarz Gender-Specific Metabolomics Approach to Kidney Cancer
description	Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific <sup>1</sup>H NMR serum metabolic profiles of RCC patients and their matched controls. A number of differential metabolites were shared by male and female RCC patients. These RCC specific changes included lower lactate, threonine, histidine, and choline levels together with increased levels of pyruvate, <i>N</i>-acetylated glycoproteins, beta-hydroxybutyrate, acetoacetate, and lysine. Additionally, serum lactate/pyruvate ratio was a strong predictor of RCC status regardless of gender. Although only moderate changes in metabolic profiles were observed between control males and females there were substantial gender related differences among RCC patients. Gender specific metabolic features associated with RCC status were identified suggesting that different metabolic panels could be leveraged for a more precise diagnostic.
format	article
author	Stanisław Deja Adam Litarski Karolina Anna Mielko Natalia Pudełko-Malik Wojciech Wojtowicz Adam Zabek Tomasz Szydełko Piotr Młynarz
author_facet	Stanisław Deja Adam Litarski Karolina Anna Mielko Natalia Pudełko-Malik Wojciech Wojtowicz Adam Zabek Tomasz Szydełko Piotr Młynarz
author_sort	Stanisław Deja
title	Gender-Specific Metabolomics Approach to Kidney Cancer
title_short	Gender-Specific Metabolomics Approach to Kidney Cancer
title_full	Gender-Specific Metabolomics Approach to Kidney Cancer
title_fullStr	Gender-Specific Metabolomics Approach to Kidney Cancer
title_full_unstemmed	Gender-Specific Metabolomics Approach to Kidney Cancer
title_sort	gender-specific metabolomics approach to kidney cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/87acef478051402aae3c68d39686ab82
work_keys_str_mv	AT stanisławdeja genderspecificmetabolomicsapproachtokidneycancer AT adamlitarski genderspecificmetabolomicsapproachtokidneycancer AT karolinaannamielko genderspecificmetabolomicsapproachtokidneycancer AT nataliapudełkomalik genderspecificmetabolomicsapproachtokidneycancer AT wojciechwojtowicz genderspecificmetabolomicsapproachtokidneycancer AT adamzabek genderspecificmetabolomicsapproachtokidneycancer AT tomaszszydełko genderspecificmetabolomicsapproachtokidneycancer AT piotrmłynarz genderspecificmetabolomicsapproachtokidneycancer
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Gender-Specific Metabolomics Approach to Kidney Cancer

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