Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection

. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.

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Autores principales: Mark J. McCarron, Magali Irla, Arnauld Sergé, Saidi M’Homa Soudja, Julien C. Marie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/87adb1264ac9462da662d251d3aa3047
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spelling oai:doaj.org-article:87adb1264ac9462da662d251d3aa30472021-12-02T15:35:57ZTransforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection10.1038/s41467-019-13456-z2041-1723https://doaj.org/article/87adb1264ac9462da662d251d3aa30472019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13456-zhttps://doaj.org/toc/2041-1723. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.Mark J. McCarronMagali IrlaArnauld SergéSaidi M’Homa SoudjaJulien C. MarieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mark J. McCarron
Magali Irla
Arnauld Sergé
Saidi M’Homa Soudja
Julien C. Marie
Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
description . TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.
format article
author Mark J. McCarron
Magali Irla
Arnauld Sergé
Saidi M’Homa Soudja
Julien C. Marie
author_facet Mark J. McCarron
Magali Irla
Arnauld Sergé
Saidi M’Homa Soudja
Julien C. Marie
author_sort Mark J. McCarron
title Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
title_short Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
title_full Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
title_fullStr Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
title_full_unstemmed Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
title_sort transforming growth factor-beta signaling in αβ thymocytes promotes negative selection
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/87adb1264ac9462da662d251d3aa3047
work_keys_str_mv AT markjmccarron transforminggrowthfactorbetasignalinginabthymocytespromotesnegativeselection
AT magaliirla transforminggrowthfactorbetasignalinginabthymocytespromotesnegativeselection
AT arnauldserge transforminggrowthfactorbetasignalinginabthymocytespromotesnegativeselection
AT saidimhomasoudja transforminggrowthfactorbetasignalinginabthymocytespromotesnegativeselection
AT juliencmarie transforminggrowthfactorbetasignalinginabthymocytespromotesnegativeselection
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