Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?

ABSTRACT Dengue viruses (DENV) cause a spectrum of disease in humans, ranging from dengue fever (DF) to a severe, life-threatening syndrome called dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Despite the global morbidity and mortality associated with DENV infection, mechanisms of immune...

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Autor principal:	Sujan Shresta
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/87b1420d290f4ace8667627cc9159e73
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spelling	oai:doaj.org-article:87b1420d290f4ace8667627cc9159e732021-11-15T15:39:03ZRole of Complement in Dengue Virus Infection: Protection or Pathogenesis?10.1128/mBio.00003-122150-7511https://doaj.org/article/87b1420d290f4ace8667627cc9159e732012-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00003-12https://doaj.org/toc/2150-7511ABSTRACT Dengue viruses (DENV) cause a spectrum of disease in humans, ranging from dengue fever (DF) to a severe, life-threatening syndrome called dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Despite the global morbidity and mortality associated with DENV infection, mechanisms of immune control and viral pathogenesis are poorly understood. In a recent article, Avirutnan et al. [mBio 2(6):e00276-11, 2011] demonstrated that DENV can be directly neutralized via the mannose binding lectin (MBL) pathway of the complement system and that deficiency in MBL level or activity due to host polymorphisms in the MBL2 gene correlates with reduced levels of DENV neutralization. These findings implicate a role for the MBL pathway in controlling DENV infections and modulating DHF/DSS manifestations.Sujan ShrestaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 1 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Sujan Shresta Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
description	ABSTRACT Dengue viruses (DENV) cause a spectrum of disease in humans, ranging from dengue fever (DF) to a severe, life-threatening syndrome called dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Despite the global morbidity and mortality associated with DENV infection, mechanisms of immune control and viral pathogenesis are poorly understood. In a recent article, Avirutnan et al. [mBio 2(6):e00276-11, 2011] demonstrated that DENV can be directly neutralized via the mannose binding lectin (MBL) pathway of the complement system and that deficiency in MBL level or activity due to host polymorphisms in the MBL2 gene correlates with reduced levels of DENV neutralization. These findings implicate a role for the MBL pathway in controlling DENV infections and modulating DHF/DSS manifestations.
format	article
author	Sujan Shresta
author_facet	Sujan Shresta
author_sort	Sujan Shresta
title	Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
title_short	Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
title_full	Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
title_fullStr	Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
title_full_unstemmed	Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?
title_sort	role of complement in dengue virus infection: protection or pathogenesis?
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/87b1420d290f4ace8667627cc9159e73
work_keys_str_mv	AT sujanshresta roleofcomplementindenguevirusinfectionprotectionorpathogenesis
_version_	1718427777180368896

Role of Complement in Dengue Virus Infection: Protection or Pathogenesis?

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