<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats

Gastric ulceration is a multifactorial disease defined as a defect in the gastric wall that extends through the muscularis mucosae into the deeper layers of the wall. The most common cause of gastric ulceration is alcohol consumption. In the current study, rats were gavaged by ethanol to investigate...

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Autores principales:	Mohamed A. Lebda, Rabab E. Mostafa, Nabil M. Taha, Eman M. Abd El-Maksoud, Hossam G. Tohamy, Soad K. Al Jaouni, Ali H. El-Far, Mohamed S. Elfeky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastric ulcer ethanol myrrh antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/87b1be0a415d4d44af3250bed41b5901
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spelling	oai:doaj.org-article:87b1be0a415d4d44af3250bed41b59012021-11-25T16:29:35Z<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats10.3390/antiox101118362076-3921https://doaj.org/article/87b1be0a415d4d44af3250bed41b59012021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1836https://doaj.org/toc/2076-3921Gastric ulceration is a multifactorial disease defined as a defect in the gastric wall that extends through the muscularis mucosae into the deeper layers of the wall. The most common cause of gastric ulceration is alcohol consumption. In the current study, rats were gavaged by ethanol to investigate the protective (before ethanol) and curative (after ethanol) ability of <i>Commiphora myrrh</i> (myrrh) oil and extract against gastric ulcer oxidative alterations induced by ethanol. Myrrh significantly improved ulcer index, histomorphology, and periodic acid Schiff (PAS) impaired by ethanol. In addition, myrrh improved the antioxidant potential of gastric mucosa through enhancement of nuclear factor related to erythroid 2 (Nrf2), total glutathione (GSH), reduced GSH, and oxidized glutathione (GSSG), along with significant reduction in malondialdehyde (MDA) levels. Amelioration of gastric oxidative stress by myrrh enables gastric mucosa to counteract the ethanol’s inflammatory and apoptotic processes leading to improved gastric proliferation and healing. Interestingly, myrrh extract showed better protective and curative effects than myrrh oil against gastric ulceration.Mohamed A. LebdaRabab E. MostafaNabil M. TahaEman M. Abd El-MaksoudHossam G. TohamySoad K. Al JaouniAli H. El-FarMohamed S. ElfekyMDPI AGarticlegastric ulcerethanolmyrrhantioxidantTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1836, p 1836 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric ulcer ethanol myrrh antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	gastric ulcer ethanol myrrh antioxidant Therapeutics. Pharmacology RM1-950 Mohamed A. Lebda Rabab E. Mostafa Nabil M. Taha Eman M. Abd El-Maksoud Hossam G. Tohamy Soad K. Al Jaouni Ali H. El-Far Mohamed S. Elfeky <i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
description	Gastric ulceration is a multifactorial disease defined as a defect in the gastric wall that extends through the muscularis mucosae into the deeper layers of the wall. The most common cause of gastric ulceration is alcohol consumption. In the current study, rats were gavaged by ethanol to investigate the protective (before ethanol) and curative (after ethanol) ability of <i>Commiphora myrrh</i> (myrrh) oil and extract against gastric ulcer oxidative alterations induced by ethanol. Myrrh significantly improved ulcer index, histomorphology, and periodic acid Schiff (PAS) impaired by ethanol. In addition, myrrh improved the antioxidant potential of gastric mucosa through enhancement of nuclear factor related to erythroid 2 (Nrf2), total glutathione (GSH), reduced GSH, and oxidized glutathione (GSSG), along with significant reduction in malondialdehyde (MDA) levels. Amelioration of gastric oxidative stress by myrrh enables gastric mucosa to counteract the ethanol’s inflammatory and apoptotic processes leading to improved gastric proliferation and healing. Interestingly, myrrh extract showed better protective and curative effects than myrrh oil against gastric ulceration.
format	article
author	Mohamed A. Lebda Rabab E. Mostafa Nabil M. Taha Eman M. Abd El-Maksoud Hossam G. Tohamy Soad K. Al Jaouni Ali H. El-Far Mohamed S. Elfeky
author_facet	Mohamed A. Lebda Rabab E. Mostafa Nabil M. Taha Eman M. Abd El-Maksoud Hossam G. Tohamy Soad K. Al Jaouni Ali H. El-Far Mohamed S. Elfeky
author_sort	Mohamed A. Lebda
title	<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
title_short	<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
title_full	<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
title_fullStr	<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
title_full_unstemmed	<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats
title_sort	<i>commiphora myrrh</i> supplementation protects and cures ethanol-induced oxidative alterations of gastric ulceration in rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/87b1be0a415d4d44af3250bed41b5901
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<i>Commiphora myrrh</i> Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats

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