Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland
Purpose: To determine the clinical significance of diffuse uptake of 68Ga-FAPI in the thyroid.Methods: From January 2020 to September 2021, all subjects with diffuse thyroid uptake in 68Ga-FAPI PET/CT were investigated in our hospital, and compared with the age and sex matched control group. The 68G...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:87b3e2020ffb4d90ab528f7da14a07d02021-11-30T12:22:29ZClinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland2296-858X10.3389/fmed.2021.782231https://doaj.org/article/87b3e2020ffb4d90ab528f7da14a07d02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.782231/fullhttps://doaj.org/toc/2296-858XPurpose: To determine the clinical significance of diffuse uptake of 68Ga-FAPI in the thyroid.Methods: From January 2020 to September 2021, all subjects with diffuse thyroid uptake in 68Ga-FAPI PET/CT were investigated in our hospital, and compared with the age and sex matched control group. The 68Ga-FAPI uptake in the thyroid gland was analyzed semi-quantitatively using the maximum standardized uptake value (SUVmax), and regression analysis was used to analyze the correlation between available serum thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb).Results: Among 815 subjects, 39 subjects were found diffuse FAPI uptake in thyroid gland; 11 subjects refused further examination; a total of 28 subjects were included in the analysis, and 27 subjects were diagnosed with chronic thyroiditis (including 20 subjects with Hashimoto's thyroiditis), 3 subjects with Grave's disease, 3 subjects with only serum TSH elevated, and 1 subject with malignant of thyroid and thyroiditis. The SUVmax of 27 subjects with thyroiditis was 5.75 ± 5.45. No significant correlation was found between the SUVmax and the level of serum TSH (P = 0.389) or TPOAb (P = 0.426).Conclusion: The incidentally discovered diffusely increased 68Ga-FAPI uptake in the thyroid gland is mostly related to chronic lymphocytic (Hashimoto's) thyroiditis. 68Ga-FAPI uptake level correlated neither with the degree of hypothyroidism nor with the titer of TPOAb. In addition, immune-related thyroiditis with immune checkpoint inhibitors may be accidentally found on 68Ga-FAPI, which may be helpful in facilitate timely intervention.Huipan LiuHuipan LiuHuipan LiuXiao YangXiao YangXiao YangLin LiuLin LiuLin LiuLei LeiLei LeiLei LeiLi WangLi WangLi WangYue ChenYue ChenYue ChenFrontiers Media S.A.articleendocrinologyPET/CT68Ga-FAPIdiffuse thyroid uptakethyroiditisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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endocrinology PET/CT 68Ga-FAPI diffuse thyroid uptake thyroiditis Medicine (General) R5-920 |
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endocrinology PET/CT 68Ga-FAPI diffuse thyroid uptake thyroiditis Medicine (General) R5-920 Huipan Liu Huipan Liu Huipan Liu Xiao Yang Xiao Yang Xiao Yang Lin Liu Lin Liu Lin Liu Lei Lei Lei Lei Lei Lei Li Wang Li Wang Li Wang Yue Chen Yue Chen Yue Chen Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| description |
Purpose: To determine the clinical significance of diffuse uptake of 68Ga-FAPI in the thyroid.Methods: From January 2020 to September 2021, all subjects with diffuse thyroid uptake in 68Ga-FAPI PET/CT were investigated in our hospital, and compared with the age and sex matched control group. The 68Ga-FAPI uptake in the thyroid gland was analyzed semi-quantitatively using the maximum standardized uptake value (SUVmax), and regression analysis was used to analyze the correlation between available serum thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb).Results: Among 815 subjects, 39 subjects were found diffuse FAPI uptake in thyroid gland; 11 subjects refused further examination; a total of 28 subjects were included in the analysis, and 27 subjects were diagnosed with chronic thyroiditis (including 20 subjects with Hashimoto's thyroiditis), 3 subjects with Grave's disease, 3 subjects with only serum TSH elevated, and 1 subject with malignant of thyroid and thyroiditis. The SUVmax of 27 subjects with thyroiditis was 5.75 ± 5.45. No significant correlation was found between the SUVmax and the level of serum TSH (P = 0.389) or TPOAb (P = 0.426).Conclusion: The incidentally discovered diffusely increased 68Ga-FAPI uptake in the thyroid gland is mostly related to chronic lymphocytic (Hashimoto's) thyroiditis. 68Ga-FAPI uptake level correlated neither with the degree of hypothyroidism nor with the titer of TPOAb. In addition, immune-related thyroiditis with immune checkpoint inhibitors may be accidentally found on 68Ga-FAPI, which may be helpful in facilitate timely intervention. |
| format |
article |
| author |
Huipan Liu Huipan Liu Huipan Liu Xiao Yang Xiao Yang Xiao Yang Lin Liu Lin Liu Lin Liu Lei Lei Lei Lei Lei Lei Li Wang Li Wang Li Wang Yue Chen Yue Chen Yue Chen |
| author_facet |
Huipan Liu Huipan Liu Huipan Liu Xiao Yang Xiao Yang Xiao Yang Lin Liu Lin Liu Lin Liu Lei Lei Lei Lei Lei Lei Li Wang Li Wang Li Wang Yue Chen Yue Chen Yue Chen |
| author_sort |
Huipan Liu |
| title |
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| title_short |
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| title_full |
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| title_fullStr |
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| title_full_unstemmed |
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland |
| title_sort |
clinical significance of diffusely increased uptake of 68ga-fapi in thyroid gland |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/87b3e2020ffb4d90ab528f7da14a07d0 |
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