Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron model across three stages of differentiation.

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Autores principales:	Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
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spelling	oai:doaj.org-article:87b561b18c73423d8f4af95c3968229a2021-11-21T12:35:47ZCis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits10.1038/s41467-021-27001-42041-1723https://doaj.org/article/87b561b18c73423d8f4af95c3968229a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27001-4https://doaj.org/toc/2041-1723Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron model across three stages of differentiation.Matthew C. PahlClaudia A. DoegeKenyaita M. HodgeSheridan H. LittletonMichelle E. LeonardSumei LuRick RauschJames A. PippinMaria Caterina De RosaAlisha BasakJonathan P. BradfieldReza K. HammondKeith BoehmRobert I. BerkowitzChiara LasconiChun SuAlessandra ChesiMatthew E. JohnsonAndrew D. WellsBenjamin F. VoightRudolph L. LeibelDiana L. CousminerStruan F. A. GrantNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew C. Pahl Claudia A. Doege Kenyaita M. Hodge Sheridan H. Littleton Michelle E. Leonard Sumei Lu Rick Rausch James A. Pippin Maria Caterina De Rosa Alisha Basak Jonathan P. Bradfield Reza K. Hammond Keith Boehm Robert I. Berkowitz Chiara Lasconi Chun Su Alessandra Chesi Matthew E. Johnson Andrew D. Wells Benjamin F. Voight Rudolph L. Leibel Diana L. Cousminer Struan F. A. Grant Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
description	Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron model across three stages of differentiation.
format	article
author	Matthew C. Pahl Claudia A. Doege Kenyaita M. Hodge Sheridan H. Littleton Michelle E. Leonard Sumei Lu Rick Rausch James A. Pippin Maria Caterina De Rosa Alisha Basak Jonathan P. Bradfield Reza K. Hammond Keith Boehm Robert I. Berkowitz Chiara Lasconi Chun Su Alessandra Chesi Matthew E. Johnson Andrew D. Wells Benjamin F. Voight Rudolph L. Leibel Diana L. Cousminer Struan F. A. Grant
author_facet	Matthew C. Pahl Claudia A. Doege Kenyaita M. Hodge Sheridan H. Littleton Michelle E. Leonard Sumei Lu Rick Rausch James A. Pippin Maria Caterina De Rosa Alisha Basak Jonathan P. Bradfield Reza K. Hammond Keith Boehm Robert I. Berkowitz Chiara Lasconi Chun Su Alessandra Chesi Matthew E. Johnson Andrew D. Wells Benjamin F. Voight Rudolph L. Leibel Diana L. Cousminer Struan F. A. Grant
author_sort	Matthew C. Pahl
title	Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
title_short	Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
title_full	Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
title_fullStr	Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
title_full_unstemmed	Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
title_sort	cis-regulatory architecture of human esc-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
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Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

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