Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:87b56e8954a142f890cbf28e5920c87e2021-11-09T06:08:37ZTraditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension1663-981210.3389/fphar.2021.720873https://doaj.org/article/87b56e8954a142f890cbf28e5920c87e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.720873/fullhttps://doaj.org/toc/1663-9812Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral drugs on trial) therapies available, PAH remains a serious and fatal pulmonary disease. As a unique medical treatment, traditional herbal medicine (THM) treatment has gradually exerted its advantages in treating PAH worldwide through a multi-level and multi-target approach. Additionally, the potential mechanisms of THM were deciphered, including suppression of proliferation and apoptosis of pulmonary artery smooth muscle cells, controlling the processes of inflammation and oxidative stress, and regulating vasoconstriction and ion channels. In this review, the effects and mechanisms of the frequently studied compound THM, single herbal preparations, and multiple active components from THM are comprehensively summarized, as well as their related mechanisms on several classical preclinical PAH models. It is worth mentioning that sodium tanshinone IIA sulfonate sodium and tetramethylpyrazine are under clinical trials and are considered the most promoting medicines for PAH treatment. Last, reverse pharmacology, a strategy to discover THM or THM-derived components, has also been proposed here for PAH. This review discusses the current state of THM, their working mechanisms against PAH, and prospects of reverse pharmacology, which are expected to facilitate the natural anti-PAH medicine discovery and development and its bench-to-bedside transformation.Zhifeng XueZhifeng XueYixuan LiYixuan LiMengen ZhouMengen ZhouZhidong LiuZhidong LiuGuanwei FanGuanwei FanXiaoying WangXiaoying WangYan ZhuYan ZhuJian YangJian YangFrontiers Media S.A.articletraditional herbal medicinespulmonary arterial hypertensionactive componentsreverse pharmacologymechanismTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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| collection |
DOAJ |
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| topic |
traditional herbal medicines pulmonary arterial hypertension active components reverse pharmacology mechanism Therapeutics. Pharmacology RM1-950 |
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traditional herbal medicines pulmonary arterial hypertension active components reverse pharmacology mechanism Therapeutics. Pharmacology RM1-950 Zhifeng Xue Zhifeng Xue Yixuan Li Yixuan Li Mengen Zhou Mengen Zhou Zhidong Liu Zhidong Liu Guanwei Fan Guanwei Fan Xiaoying Wang Xiaoying Wang Yan Zhu Yan Zhu Jian Yang Jian Yang Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| description |
Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral drugs on trial) therapies available, PAH remains a serious and fatal pulmonary disease. As a unique medical treatment, traditional herbal medicine (THM) treatment has gradually exerted its advantages in treating PAH worldwide through a multi-level and multi-target approach. Additionally, the potential mechanisms of THM were deciphered, including suppression of proliferation and apoptosis of pulmonary artery smooth muscle cells, controlling the processes of inflammation and oxidative stress, and regulating vasoconstriction and ion channels. In this review, the effects and mechanisms of the frequently studied compound THM, single herbal preparations, and multiple active components from THM are comprehensively summarized, as well as their related mechanisms on several classical preclinical PAH models. It is worth mentioning that sodium tanshinone IIA sulfonate sodium and tetramethylpyrazine are under clinical trials and are considered the most promoting medicines for PAH treatment. Last, reverse pharmacology, a strategy to discover THM or THM-derived components, has also been proposed here for PAH. This review discusses the current state of THM, their working mechanisms against PAH, and prospects of reverse pharmacology, which are expected to facilitate the natural anti-PAH medicine discovery and development and its bench-to-bedside transformation. |
| format |
article |
| author |
Zhifeng Xue Zhifeng Xue Yixuan Li Yixuan Li Mengen Zhou Mengen Zhou Zhidong Liu Zhidong Liu Guanwei Fan Guanwei Fan Xiaoying Wang Xiaoying Wang Yan Zhu Yan Zhu Jian Yang Jian Yang |
| author_facet |
Zhifeng Xue Zhifeng Xue Yixuan Li Yixuan Li Mengen Zhou Mengen Zhou Zhidong Liu Zhidong Liu Guanwei Fan Guanwei Fan Xiaoying Wang Xiaoying Wang Yan Zhu Yan Zhu Jian Yang Jian Yang |
| author_sort |
Zhifeng Xue |
| title |
Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| title_short |
Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| title_full |
Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| title_fullStr |
Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| title_full_unstemmed |
Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension |
| title_sort |
traditional herbal medicine discovery for the treatment and prevention of pulmonary arterial hypertension |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/87b56e8954a142f890cbf28e5920c87e |
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