SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

A better understanding of longitudinal changes in antibody responses in COVID-19 patients is needed. Here the authors analyze anti-spike and anti-nucleocapsid antibody responses to Sars-CoV-2 over a course of 6 months in a large cohort of patients with COVID-19, showing that IgM is mostly not detect...

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Autores principales:	Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87b5e3b2d655425da4c2ff45fb7884d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:87b5e3b2d655425da4c2ff45fb7884d02021-12-02T17:04:01ZSARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-1910.1038/s41467-021-22034-12041-1723https://doaj.org/article/87b5e3b2d655425da4c2ff45fb7884d02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22034-1https://doaj.org/toc/2041-1723A better understanding of longitudinal changes in antibody responses in COVID-19 patients is needed. Here the authors analyze anti-spike and anti-nucleocapsid antibody responses to Sars-CoV-2 over a course of 6 months in a large cohort of patients with COVID-19, showing that IgM is mostly not detectable after 3 months, whereas IgG responses contract, yet remain at high levels at 6 months.Jun WuBoyun LiangCunrong ChenHua WangYaohui FangShu ShenXiaoli YangBaoju WangLiangkai ChenQi ChenYang WuJia LiuXuecheng YangWei LiBin ZhuWenqing ZhouHuan WangSumeng LiSihong LuDi LiuHuadong LiAdalbert KrawczykMengji LuDongliang YangFei DengUlf DittmerMirko TrillingXin ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Wu Boyun Liang Cunrong Chen Hua Wang Yaohui Fang Shu Shen Xiaoli Yang Baoju Wang Liangkai Chen Qi Chen Yang Wu Jia Liu Xuecheng Yang Wei Li Bin Zhu Wenqing Zhou Huan Wang Sumeng Li Sihong Lu Di Liu Huadong Li Adalbert Krawczyk Mengji Lu Dongliang Yang Fei Deng Ulf Dittmer Mirko Trilling Xin Zheng SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
description	A better understanding of longitudinal changes in antibody responses in COVID-19 patients is needed. Here the authors analyze anti-spike and anti-nucleocapsid antibody responses to Sars-CoV-2 over a course of 6 months in a large cohort of patients with COVID-19, showing that IgM is mostly not detectable after 3 months, whereas IgG responses contract, yet remain at high levels at 6 months.
format	article
author	Jun Wu Boyun Liang Cunrong Chen Hua Wang Yaohui Fang Shu Shen Xiaoli Yang Baoju Wang Liangkai Chen Qi Chen Yang Wu Jia Liu Xuecheng Yang Wei Li Bin Zhu Wenqing Zhou Huan Wang Sumeng Li Sihong Lu Di Liu Huadong Li Adalbert Krawczyk Mengji Lu Dongliang Yang Fei Deng Ulf Dittmer Mirko Trilling Xin Zheng
author_facet	Jun Wu Boyun Liang Cunrong Chen Hua Wang Yaohui Fang Shu Shen Xiaoli Yang Baoju Wang Liangkai Chen Qi Chen Yang Wu Jia Liu Xuecheng Yang Wei Li Bin Zhu Wenqing Zhou Huan Wang Sumeng Li Sihong Lu Di Liu Huadong Li Adalbert Krawczyk Mengji Lu Dongliang Yang Fei Deng Ulf Dittmer Mirko Trilling Xin Zheng
author_sort	Jun Wu
title	SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
title_short	SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
title_full	SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
title_fullStr	SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
title_full_unstemmed	SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
title_sort	sars-cov-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87b5e3b2d655425da4c2ff45fb7884d0
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SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

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