Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.

<h4>Background and aim</h4>Maternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given the lack of specificity for both the exposures and the outcomes, other factors related to infection such as impaired maternal immune f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chun S Wu, Lars H Pedersen, Jessica E Miller, Yuelian Sun, Elani Streja, Peter Uldall, Jørn Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87b655a572e74cd39b004a3b966d97ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:87b655a572e74cd39b004a3b966d97ac
record_format	dspace
spelling	oai:doaj.org-article:87b655a572e74cd39b004a3b966d97ac2021-11-18T07:55:47ZRisk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.1932-620310.1371/journal.pone.0057552https://doaj.org/article/87b655a572e74cd39b004a3b966d97ac2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23460873/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aim</h4>Maternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given the lack of specificity for both the exposures and the outcomes, other factors related to infection such as impaired maternal immune function may be involved in the causal pathway. If impaired maternal immune function plays a role, we would expect infection before pregnancy to be associated with these neurological outcomes.<h4>Methods/principal findings</h4>The study population included all first-born singletons in Denmark between January 1 1982 and December 31 2004. We identified women who had hospital-recorded infections within the 5 year period before pregnancy, and women who had hospital-recorded infections during pregnancy. We grouped infections into either infections of the genitourinary system, or any other infections. Cox models were used to estimate adjusted hazard ratios (aHRs) with 95% confidence interval (CI). Maternal infection of the genitourinary system during pregnancy was associated with an increased risk of cerebral palsy (aHR = 1.63, 95% CI: 1.34-1.98) and epilepsy (aHR = 1.27, 95% CI: 1.13-1.42) in the children, compared to children of women without infections during pregnancy. Among women without hospital-recorded infections during pregnancy, maternal infection before pregnancy was associated with an increased risk of epilepsy (aHR = 1.35, 95% CI: 1.21-1.50 for infections of the genitourinary system, and HR = 1.12, 95% CI: 1.03-1.22 for any other infections) and a slightly higher risk of cerebral palsy (aHR = 1.20, 95% CI: 0.96-1.49 for infections of the genitourinary system, and HR = 1.23, 95% CI: 1.06-1.43 for any other infections) in the children, compared to children of women without infections before (and during) pregnancy.<h4>Conclusions</h4>These findings indicate that the maternal immune system, maternal infections, or factors related to maternal immune function play a role in the observed associations between maternal infections before pregnancy and cerebral diseases in the offspring.Chun S WuLars H PedersenJessica E MillerYuelian SunElani StrejaPeter UldallJørn OlsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57552 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun S Wu Lars H Pedersen Jessica E Miller Yuelian Sun Elani Streja Peter Uldall Jørn Olsen Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
description	<h4>Background and aim</h4>Maternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given the lack of specificity for both the exposures and the outcomes, other factors related to infection such as impaired maternal immune function may be involved in the causal pathway. If impaired maternal immune function plays a role, we would expect infection before pregnancy to be associated with these neurological outcomes.<h4>Methods/principal findings</h4>The study population included all first-born singletons in Denmark between January 1 1982 and December 31 2004. We identified women who had hospital-recorded infections within the 5 year period before pregnancy, and women who had hospital-recorded infections during pregnancy. We grouped infections into either infections of the genitourinary system, or any other infections. Cox models were used to estimate adjusted hazard ratios (aHRs) with 95% confidence interval (CI). Maternal infection of the genitourinary system during pregnancy was associated with an increased risk of cerebral palsy (aHR = 1.63, 95% CI: 1.34-1.98) and epilepsy (aHR = 1.27, 95% CI: 1.13-1.42) in the children, compared to children of women without infections during pregnancy. Among women without hospital-recorded infections during pregnancy, maternal infection before pregnancy was associated with an increased risk of epilepsy (aHR = 1.35, 95% CI: 1.21-1.50 for infections of the genitourinary system, and HR = 1.12, 95% CI: 1.03-1.22 for any other infections) and a slightly higher risk of cerebral palsy (aHR = 1.20, 95% CI: 0.96-1.49 for infections of the genitourinary system, and HR = 1.23, 95% CI: 1.06-1.43 for any other infections) in the children, compared to children of women without infections before (and during) pregnancy.<h4>Conclusions</h4>These findings indicate that the maternal immune system, maternal infections, or factors related to maternal immune function play a role in the observed associations between maternal infections before pregnancy and cerebral diseases in the offspring.
format	article
author	Chun S Wu Lars H Pedersen Jessica E Miller Yuelian Sun Elani Streja Peter Uldall Jørn Olsen
author_facet	Chun S Wu Lars H Pedersen Jessica E Miller Yuelian Sun Elani Streja Peter Uldall Jørn Olsen
author_sort	Chun S Wu
title	Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
title_short	Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
title_full	Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
title_fullStr	Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
title_full_unstemmed	Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
title_sort	risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/87b655a572e74cd39b004a3b966d97ac
work_keys_str_mv	AT chunswu riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT larshpedersen riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT jessicaemiller riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT yueliansun riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT elanistreja riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT peteruldall riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy AT jørnolsen riskofcerebralpalsyandchildhoodepilepsyrelatedtoinfectionsbeforeorduringpregnancy
_version_	1718422742549659648

Risk of cerebral palsy and childhood epilepsy related to infections before or during pregnancy.

Ejemplares similares