Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma

Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma

Ibrutinib has demonstrated high response rates in B-cell lymphomas but a lot of ibrutinib-treated patients relapse with resistance. This study unified TME-mediatedde novoand acquired drug resistance through B-cell receptor signalling and PI3K-AKT-mTOR axis and provides a combination therapeutic stra...

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Autores principales: Xiaohong Zhao, Tint Lwin, Ariosto Silva, Bijal Shah, Jiangchuan Tao, Bin Fang, Liang Zhang, Kai Fu, Chengfeng Bi, Jiannong Li, Huijuan Jiang, Mark B. Meads, Timothy Jacobson, Maria Silva, Allison Distler, Lancia Darville, Ling Zhang, Ying Han, Dmitri Rebatchouk, Maurizio Di Liberto, Lynn C. Moscinski, John M. Koomen, William S. Dalton, Kenneth H. Shain, Michael Wang, Eduardo Sotomayor, Jianguo Tao
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/87b74c23a81c4b28a5b297ad5bef630b
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spelling oai:doaj.org-article:87b74c23a81c4b28a5b297ad5bef630b2021-12-02T14:41:10ZUnification of de novo and acquired ibrutinib resistance in mantle cell lymphoma10.1038/ncomms149202041-1723https://doaj.org/article/87b74c23a81c4b28a5b297ad5bef630b2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14920https://doaj.org/toc/2041-1723Ibrutinib has demonstrated high response rates in B-cell lymphomas but a lot of ibrutinib-treated patients relapse with resistance. This study unified TME-mediatedde novoand acquired drug resistance through B-cell receptor signalling and PI3K-AKT-mTOR axis and provides a combination therapeutic strategy against B-cell malignancies.Xiaohong ZhaoTint LwinAriosto SilvaBijal ShahJiangchuan TaoBin FangLiang ZhangKai FuChengfeng BiJiannong LiHuijuan JiangMark B. MeadsTimothy JacobsonMaria SilvaAllison DistlerLancia DarvilleLing ZhangYing HanDmitri RebatchoukMaurizio Di LibertoLynn C. MoscinskiJohn M. KoomenWilliam S. DaltonKenneth H. ShainMichael WangEduardo SotomayorJianguo TaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaohong Zhao
Tint Lwin
Ariosto Silva
Bijal Shah
Jiangchuan Tao
Bin Fang
Liang Zhang
Kai Fu
Chengfeng Bi
Jiannong Li
Huijuan Jiang
Mark B. Meads
Timothy Jacobson
Maria Silva
Allison Distler
Lancia Darville
Ling Zhang
Ying Han
Dmitri Rebatchouk
Maurizio Di Liberto
Lynn C. Moscinski
John M. Koomen
William S. Dalton
Kenneth H. Shain
Michael Wang
Eduardo Sotomayor
Jianguo Tao
Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
description Ibrutinib has demonstrated high response rates in B-cell lymphomas but a lot of ibrutinib-treated patients relapse with resistance. This study unified TME-mediatedde novoand acquired drug resistance through B-cell receptor signalling and PI3K-AKT-mTOR axis and provides a combination therapeutic strategy against B-cell malignancies.
format article
author Xiaohong Zhao
Tint Lwin
Ariosto Silva
Bijal Shah
Jiangchuan Tao
Bin Fang
Liang Zhang
Kai Fu
Chengfeng Bi
Jiannong Li
Huijuan Jiang
Mark B. Meads
Timothy Jacobson
Maria Silva
Allison Distler
Lancia Darville
Ling Zhang
Ying Han
Dmitri Rebatchouk
Maurizio Di Liberto
Lynn C. Moscinski
John M. Koomen
William S. Dalton
Kenneth H. Shain
Michael Wang
Eduardo Sotomayor
Jianguo Tao
author_facet Xiaohong Zhao
Tint Lwin
Ariosto Silva
Bijal Shah
Jiangchuan Tao
Bin Fang
Liang Zhang
Kai Fu
Chengfeng Bi
Jiannong Li
Huijuan Jiang
Mark B. Meads
Timothy Jacobson
Maria Silva
Allison Distler
Lancia Darville
Ling Zhang
Ying Han
Dmitri Rebatchouk
Maurizio Di Liberto
Lynn C. Moscinski
John M. Koomen
William S. Dalton
Kenneth H. Shain
Michael Wang
Eduardo Sotomayor
Jianguo Tao
author_sort Xiaohong Zhao
title Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
title_short Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
title_full Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
title_fullStr Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
title_full_unstemmed Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
title_sort unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/87b74c23a81c4b28a5b297ad5bef630b
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