APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA, which reveals how the APOBEC3H dimer binds aroun...

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Autores principales:	Jennifer A. Bohn, Keyur Thummar, Ashley York, Alice Raymond, W. Clay Brown, Paul D. Bieniasz, Theodora Hatziioannou, Janet L. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87b772b400884c0ab80fc87ff5e15102
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spelling	oai:doaj.org-article:87b772b400884c0ab80fc87ff5e151022021-12-02T17:06:11ZAPOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA10.1038/s41467-017-01309-62041-1723https://doaj.org/article/87b772b400884c0ab80fc87ff5e151022017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01309-6https://doaj.org/toc/2041-1723The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA, which reveals how the APOBEC3H dimer binds around a short RNA duplex.Jennifer A. BohnKeyur ThummarAshley YorkAlice RaymondW. Clay BrownPaul D. BieniaszTheodora HatziioannouJanet L. SmithNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer A. Bohn Keyur Thummar Ashley York Alice Raymond W. Clay Brown Paul D. Bieniasz Theodora Hatziioannou Janet L. Smith APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
description	The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA, which reveals how the APOBEC3H dimer binds around a short RNA duplex.
format	article
author	Jennifer A. Bohn Keyur Thummar Ashley York Alice Raymond W. Clay Brown Paul D. Bieniasz Theodora Hatziioannou Janet L. Smith
author_facet	Jennifer A. Bohn Keyur Thummar Ashley York Alice Raymond W. Clay Brown Paul D. Bieniasz Theodora Hatziioannou Janet L. Smith
author_sort	Jennifer A. Bohn
title	APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
title_short	APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
title_full	APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
title_fullStr	APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
title_full_unstemmed	APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
title_sort	apobec3h structure reveals an unusual mechanism of interaction with duplex rna
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87b772b400884c0ab80fc87ff5e15102
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APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

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