Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset

Bernardo Dell&rsquo;Osso1, Massimiliano Buoli1, Riccardo Riundi2, Nazario D&rsquo;Urso1, Sara Pozzoli1, Roberta Bassetti2, Emanuela Mundo1,&nbsp; A Carlo Altamura11Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Reg...

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Autores principales:	Bernardo Dell&rsquo;Osso, Massimiliano Buoli, Riccardo Riundi, Nazario D&rsquo;Urso, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/87bbd6410f914c1e95fc010d8067fbc5
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spelling	oai:doaj.org-article:87bbd6410f914c1e95fc010d8067fbc52021-12-02T08:25:42ZClinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset1176-63281178-2021https://doaj.org/article/87bbd6410f914c1e95fc010d8067fbc52009-07-01T00:00:00Zhttp://www.dovepress.com/clinical-characteristics-and-long-term-response-to-mood-stabilizers-in-a3355https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Bernardo Dell&rsquo;Osso1, Massimiliano Buoli1, Riccardo Riundi2, Nazario D&rsquo;Urso1, Sara Pozzoli1, Roberta Bassetti2, Emanuela Mundo1,&nbsp; A Carlo Altamura11Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy; 2Department of Clinical Sciences, Luigi Sacco, Milano, ItalyIntroduction: Bipolar disorder (BD) is a prevalent, comorbid, and impairing condition. Potential predictors of response to pharmacological treatment are object of continuous investigation in patients with BD. The present naturalistic study was aimed to assess clinical features and longterm response to mood stabilizers in a sample of bipolar subjects with different ages at onset. Methods: The study sample included 108 euthymic patients, diagnosed as affected by BD, either type I or II, according to the DSM-IV-TR, who were started on mood stabilizer treatment. Patients were followed-up for 24 months and the occurrence of any mood episode collected. At the end of the follow-up, patients were divided in&nbsp;three subgroups according to the age at onset (early-onset &le;30 years, middle-onset &gt;30&ndash;&le;45 years, and late-onset &gt;45 years, respectively) and the long-term response to mood stabilizers was compared between them along with other clinical features.Results: The three subgroups showed significant differences in terms of clinical and demographic features and, with respect to long-term response to mood stabilizers, the early-onset subgroup showed a better outcome in terms of reduction of major depressive episodes during the 24-month follow-up compared to the other subgroups (one way ANOVA, F = 3.57, p = 0.032). Conclusions: Even though further controlled studies are needed to clarify the relationship between age at onset and outcome in BD, the present follow-up study suggests clinical peculiarities and different patterns of response to mood stabilizers across distinct subgroups of patients with BD and different ages at onset.Keywords: bipolar disorder, age at onset (AAO), mood stabilizers, long-term treatment Bernardo Dell&rsquo;OssoMassimiliano BuoliRiccardo RiundiNazario D&rsquo;Ursoet al.Dove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 399-404 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bernardo Dell&rsquo;Osso Massimiliano Buoli Riccardo Riundi Nazario D&rsquo;Urso et al. Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
description	Bernardo Dell&rsquo;Osso1, Massimiliano Buoli1, Riccardo Riundi2, Nazario D&rsquo;Urso1, Sara Pozzoli1, Roberta Bassetti2, Emanuela Mundo1,&nbsp; A Carlo Altamura11Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy; 2Department of Clinical Sciences, Luigi Sacco, Milano, ItalyIntroduction: Bipolar disorder (BD) is a prevalent, comorbid, and impairing condition. Potential predictors of response to pharmacological treatment are object of continuous investigation in patients with BD. The present naturalistic study was aimed to assess clinical features and longterm response to mood stabilizers in a sample of bipolar subjects with different ages at onset. Methods: The study sample included 108 euthymic patients, diagnosed as affected by BD, either type I or II, according to the DSM-IV-TR, who were started on mood stabilizer treatment. Patients were followed-up for 24 months and the occurrence of any mood episode collected. At the end of the follow-up, patients were divided in&nbsp;three subgroups according to the age at onset (early-onset &le;30 years, middle-onset &gt;30&ndash;&le;45 years, and late-onset &gt;45 years, respectively) and the long-term response to mood stabilizers was compared between them along with other clinical features.Results: The three subgroups showed significant differences in terms of clinical and demographic features and, with respect to long-term response to mood stabilizers, the early-onset subgroup showed a better outcome in terms of reduction of major depressive episodes during the 24-month follow-up compared to the other subgroups (one way ANOVA, F = 3.57, p = 0.032). Conclusions: Even though further controlled studies are needed to clarify the relationship between age at onset and outcome in BD, the present follow-up study suggests clinical peculiarities and different patterns of response to mood stabilizers across distinct subgroups of patients with BD and different ages at onset.Keywords: bipolar disorder, age at onset (AAO), mood stabilizers, long-term treatment
format	article
author	Bernardo Dell&rsquo;Osso Massimiliano Buoli Riccardo Riundi Nazario D&rsquo;Urso et al.
author_facet	Bernardo Dell&rsquo;Osso Massimiliano Buoli Riccardo Riundi Nazario D&rsquo;Urso et al.
author_sort	Bernardo Dell&rsquo;Osso
title	Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
title_short	Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
title_full	Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
title_fullStr	Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
title_full_unstemmed	Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
title_sort	clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/87bbd6410f914c1e95fc010d8067fbc5
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Clinical characteristics and long-term response to mood stabilizers in patients with bipolar disorder and different age at onset

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