The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study

The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study

Abstract Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence o...

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Autores principales: Heng Zhang, Ying-Xue Li, Wei-Jun Peng, Zhi-Wei Li, Chun-Hua Zhang, Hai-Hong Di, Xian-Ping Shen, Jun-Feng Zhu, Wei-Rong Yan
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:87c06b3264d34628b874c43d3d7118402021-12-02T15:04:52ZThe Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study10.1038/s41598-017-05411-z2045-2322https://doaj.org/article/87c06b3264d34628b874c43d3d7118402017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05411-zhttps://doaj.org/toc/2045-2322Abstract Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence of maternal and fetal ACE I/D, ACE G2350A, AGT M235T, AGT T174M, and AT1R A1166C polymorphisms on PE in Han Chinese women. Polymorphisms were genotyped in 1,488 subjects (256 patients experiencing PE, along with their fetuses and partners, and 360 normotensive controls with their fetuses). Transmission disequilibrium tests revealed that ACE I/D (P = 0.041), ACE G2350A (P = 0.035), and AT1R A1166C (P = 0.018) were associated with maternal PE. The log-linear analyses revealed that mothers whose offspring carried the MM genotype of AGT M235T had a higher risk of PE (OR = 1.54, P = 0.010), whereas mothers whose offspring carried the II genotype of ACE I/D or the GG genotype of ACE G2350A had a reduced risk (OR = 0.58, P = 0.039; OR = 0.47, P = 0.045, respectively). Our findings demonstrate that fetal ACE I/D, ACE G2350A, AGT M235T, and AT1R A1166C polymorphisms may play significant roles in PE development among pregnant Han Chinese women.Heng ZhangYing-Xue LiWei-Jun PengZhi-Wei LiChun-Hua ZhangHai-Hong DiXian-Ping ShenJun-Feng ZhuWei-Rong YanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Heng Zhang
Ying-Xue Li
Wei-Jun Peng
Zhi-Wei Li
Chun-Hua Zhang
Hai-Hong Di
Xian-Ping Shen
Jun-Feng Zhu
Wei-Rong Yan
The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
description Abstract Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence of maternal and fetal ACE I/D, ACE G2350A, AGT M235T, AGT T174M, and AT1R A1166C polymorphisms on PE in Han Chinese women. Polymorphisms were genotyped in 1,488 subjects (256 patients experiencing PE, along with their fetuses and partners, and 360 normotensive controls with their fetuses). Transmission disequilibrium tests revealed that ACE I/D (P = 0.041), ACE G2350A (P = 0.035), and AT1R A1166C (P = 0.018) were associated with maternal PE. The log-linear analyses revealed that mothers whose offspring carried the MM genotype of AGT M235T had a higher risk of PE (OR = 1.54, P = 0.010), whereas mothers whose offspring carried the II genotype of ACE I/D or the GG genotype of ACE G2350A had a reduced risk (OR = 0.58, P = 0.039; OR = 0.47, P = 0.045, respectively). Our findings demonstrate that fetal ACE I/D, ACE G2350A, AGT M235T, and AT1R A1166C polymorphisms may play significant roles in PE development among pregnant Han Chinese women.
format article
author Heng Zhang
Ying-Xue Li
Wei-Jun Peng
Zhi-Wei Li
Chun-Hua Zhang
Hai-Hong Di
Xian-Ping Shen
Jun-Feng Zhu
Wei-Rong Yan
author_facet Heng Zhang
Ying-Xue Li
Wei-Jun Peng
Zhi-Wei Li
Chun-Hua Zhang
Hai-Hong Di
Xian-Ping Shen
Jun-Feng Zhu
Wei-Rong Yan
author_sort Heng Zhang
title The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
title_short The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
title_full The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
title_fullStr The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
title_full_unstemmed The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study
title_sort gene variants of maternal/fetal renin-angiotensin system in preeclampsia: a hybrid case-parent/mother-control study
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/87c06b3264d34628b874c43d3d711840
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