The deep and slow breathing characterizing rest favors brain respiratory-drive

Abstract A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory b...

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Autores principales:	Baptiste Girin, Maxime Juventin, Samuel Garcia, Laura Lefèvre, Corine Amat, Nicolas Fourcaud-Trocmé, Nathalie Buonviso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87ca285147e446f682c4fbaa2e987395
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spelling	oai:doaj.org-article:87ca285147e446f682c4fbaa2e9873952021-12-02T13:26:50ZThe deep and slow breathing characterizing rest favors brain respiratory-drive10.1038/s41598-021-86525-32045-2322https://doaj.org/article/87ca285147e446f682c4fbaa2e9873952021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86525-3https://doaj.org/toc/2045-2322Abstract A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb response. By leveraging spontaneous variations of respiratory dynamics during natural conditions, we investigated whether respiratory drive also varies with nasal airflow movements. We analyzed local field potential activity relative to respiratory signal in various brain regions during waking and sleep states. We found that respiration regime was state-specific, and that quiet waking was the only vigilance state during which all the recorded structures can be respiration-driven whatever the respiratory frequency. Using CO2-enriched air to alter respiratory regime associated to each state and a respiratory cycle based analysis, we evidenced that the large and strong brain drive observed during quiet waking was related to an optimal trade-off between depth and duration of inspiration in the respiratory pattern, characterizing this specific state. These results show for the first time that changes in respiration regime affect cortical dynamics and that the respiratory regime associated with rest is optimal for respiration to drive the brain.Baptiste GirinMaxime JuventinSamuel GarciaLaura LefèvreCorine AmatNicolas Fourcaud-TrocméNathalie BuonvisoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Baptiste Girin Maxime Juventin Samuel Garcia Laura Lefèvre Corine Amat Nicolas Fourcaud-Trocmé Nathalie Buonviso The deep and slow breathing characterizing rest favors brain respiratory-drive
description	Abstract A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb response. By leveraging spontaneous variations of respiratory dynamics during natural conditions, we investigated whether respiratory drive also varies with nasal airflow movements. We analyzed local field potential activity relative to respiratory signal in various brain regions during waking and sleep states. We found that respiration regime was state-specific, and that quiet waking was the only vigilance state during which all the recorded structures can be respiration-driven whatever the respiratory frequency. Using CO2-enriched air to alter respiratory regime associated to each state and a respiratory cycle based analysis, we evidenced that the large and strong brain drive observed during quiet waking was related to an optimal trade-off between depth and duration of inspiration in the respiratory pattern, characterizing this specific state. These results show for the first time that changes in respiration regime affect cortical dynamics and that the respiratory regime associated with rest is optimal for respiration to drive the brain.
format	article
author	Baptiste Girin Maxime Juventin Samuel Garcia Laura Lefèvre Corine Amat Nicolas Fourcaud-Trocmé Nathalie Buonviso
author_facet	Baptiste Girin Maxime Juventin Samuel Garcia Laura Lefèvre Corine Amat Nicolas Fourcaud-Trocmé Nathalie Buonviso
author_sort	Baptiste Girin
title	The deep and slow breathing characterizing rest favors brain respiratory-drive
title_short	The deep and slow breathing characterizing rest favors brain respiratory-drive
title_full	The deep and slow breathing characterizing rest favors brain respiratory-drive
title_fullStr	The deep and slow breathing characterizing rest favors brain respiratory-drive
title_full_unstemmed	The deep and slow breathing characterizing rest favors brain respiratory-drive
title_sort	deep and slow breathing characterizing rest favors brain respiratory-drive
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87ca285147e446f682c4fbaa2e987395
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The deep and slow breathing characterizing rest favors brain respiratory-drive

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