Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis

Abstract The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation...

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Autores principales:	Jasmina Djuretić, Mirjana Dimitrijević, Marija Stojanović, Jelena Kotur Stevuljević, Michael R. Hamblin, Ana Micov, Radica Stepanović-Petrović, Gordana Leposavić
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87cad5b1bb60468d882a7571994c20ce
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spelling	oai:doaj.org-article:87cad5b1bb60468d882a7571994c20ce2021-12-02T10:44:15ZInfrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis10.1038/s41598-021-81999-72045-2322https://doaj.org/article/87cad5b1bb60468d882a7571994c20ce2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81999-7https://doaj.org/toc/2045-2322Abstract The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.Jasmina DjuretićMirjana DimitrijevićMarija StojanovićJelena Kotur StevuljevićMichael R. HamblinAna MicovRadica Stepanović-PetrovićGordana LeposavićNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasmina Djuretić Mirjana Dimitrijević Marija Stojanović Jelena Kotur Stevuljević Michael R. Hamblin Ana Micov Radica Stepanović-Petrović Gordana Leposavić Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
description	Abstract The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.
format	article
author	Jasmina Djuretić Mirjana Dimitrijević Marija Stojanović Jelena Kotur Stevuljević Michael R. Hamblin Ana Micov Radica Stepanović-Petrović Gordana Leposavić
author_facet	Jasmina Djuretić Mirjana Dimitrijević Marija Stojanović Jelena Kotur Stevuljević Michael R. Hamblin Ana Micov Radica Stepanović-Petrović Gordana Leposavić
author_sort	Jasmina Djuretić
title	Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
title_short	Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
title_full	Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
title_fullStr	Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
title_full_unstemmed	Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
title_sort	infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87cad5b1bb60468d882a7571994c20ce
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Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis

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