Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats

Abstract Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can...

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Autores principales:	Gao-Feng Wu, Shuang Ren, Ri-Yi Tang, Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu, Jian-Cheng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87d0e3a5c03b411dbe00f3685a2e9461
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spelling	oai:doaj.org-article:87d0e3a5c03b411dbe00f3685a2e94612021-12-02T12:32:19ZAntidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats10.1038/s41598-017-05051-32045-2322https://doaj.org/article/87d0e3a5c03b411dbe00f3685a2e94612017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05051-3https://doaj.org/toc/2045-2322Abstract Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can improve learning ability and memory. Our study investigated the antidepressant-like effects of taurine pre-treatment by examining the changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors and neurotrophic factors in the hippocampus of a chronic unpredictable mild stress (CUMS)-induced depressive rat model. Taurine was found to inhibit the decrease of sucrose consumption and prevent the deficiency of spatial memory and anxiety in rats exposed to CUMS, suggesting a preventive effect of taurine on depression-like behavior. Furthermore, the decreased levels of 5-hydroxytryptamine, dopamine, noradrenaline; the increased levels of glutamate, corticosterone; and the decreased expressions of fibroblast growth factor-2, vascular endothelial growth factor and brain derived neurotrophic factor in depressive rats were hindered by taurine pre-administration. However, tumor necrosis factor-α and interleukin-1β levels were not significantly changed by taurine. The results demonstrated that the anti-depressive effect of taurine may be involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and the promotion of neurogenesis, neuronal survival and growth in the hippocampus.Gao-Feng WuShuang RenRi-Yi TangChang XuJia-Qi ZhouShu-Mei LinYing FengQun-Hui YangJian-Min HuJian-Cheng YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gao-Feng Wu Shuang Ren Ri-Yi Tang Chang Xu Jia-Qi Zhou Shu-Mei Lin Ying Feng Qun-Hui Yang Jian-Min Hu Jian-Cheng Yang Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
description	Abstract Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can improve learning ability and memory. Our study investigated the antidepressant-like effects of taurine pre-treatment by examining the changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors and neurotrophic factors in the hippocampus of a chronic unpredictable mild stress (CUMS)-induced depressive rat model. Taurine was found to inhibit the decrease of sucrose consumption and prevent the deficiency of spatial memory and anxiety in rats exposed to CUMS, suggesting a preventive effect of taurine on depression-like behavior. Furthermore, the decreased levels of 5-hydroxytryptamine, dopamine, noradrenaline; the increased levels of glutamate, corticosterone; and the decreased expressions of fibroblast growth factor-2, vascular endothelial growth factor and brain derived neurotrophic factor in depressive rats were hindered by taurine pre-administration. However, tumor necrosis factor-α and interleukin-1β levels were not significantly changed by taurine. The results demonstrated that the anti-depressive effect of taurine may be involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and the promotion of neurogenesis, neuronal survival and growth in the hippocampus.
format	article
author	Gao-Feng Wu Shuang Ren Ri-Yi Tang Chang Xu Jia-Qi Zhou Shu-Mei Lin Ying Feng Qun-Hui Yang Jian-Min Hu Jian-Cheng Yang
author_facet	Gao-Feng Wu Shuang Ren Ri-Yi Tang Chang Xu Jia-Qi Zhou Shu-Mei Lin Ying Feng Qun-Hui Yang Jian-Min Hu Jian-Cheng Yang
author_sort	Gao-Feng Wu
title	Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
title_short	Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
title_full	Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
title_fullStr	Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
title_full_unstemmed	Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
title_sort	antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87d0e3a5c03b411dbe00f3685a2e9461
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Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats

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