Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.

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Autores principales:	Sonja Reißig, Yilang Tang, Alexei Nikolaev, Katharina Gerlach, Christine Wolf, Kathrin Davari, Christian Gallus, Joumana Masri, Ilgiz A. Mufazalov, Markus F. Neurath, F. Thomas Wunderlich, Jörn M. Schattenberg, Peter R. Galle, Benno Weigmann, Ari Waisman, Elke Glasmacher, Nadine Hövelmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87d328bf46c940f9b17786b9c4f283ce
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spelling	oai:doaj.org-article:87d328bf46c940f9b17786b9c4f283ce2021-12-02T14:41:08ZElevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis10.1038/ncomms150692041-1723https://doaj.org/article/87d328bf46c940f9b17786b9c4f283ce2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15069https://doaj.org/toc/2041-1723Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.Sonja ReißigYilang TangAlexei NikolaevKatharina GerlachChristine WolfKathrin DavariChristian GallusJoumana MasriIlgiz A. MufazalovMarkus F. NeurathF. Thomas WunderlichJörn M. SchattenbergPeter R. GalleBenno WeigmannAri WaismanElke GlasmacherNadine HövelmeyerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonja Reißig Yilang Tang Alexei Nikolaev Katharina Gerlach Christine Wolf Kathrin Davari Christian Gallus Joumana Masri Ilgiz A. Mufazalov Markus F. Neurath F. Thomas Wunderlich Jörn M. Schattenberg Peter R. Galle Benno Weigmann Ari Waisman Elke Glasmacher Nadine Hövelmeyer Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
description	Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.
format	article
author	Sonja Reißig Yilang Tang Alexei Nikolaev Katharina Gerlach Christine Wolf Kathrin Davari Christian Gallus Joumana Masri Ilgiz A. Mufazalov Markus F. Neurath F. Thomas Wunderlich Jörn M. Schattenberg Peter R. Galle Benno Weigmann Ari Waisman Elke Glasmacher Nadine Hövelmeyer
author_facet	Sonja Reißig Yilang Tang Alexei Nikolaev Katharina Gerlach Christine Wolf Kathrin Davari Christian Gallus Joumana Masri Ilgiz A. Mufazalov Markus F. Neurath F. Thomas Wunderlich Jörn M. Schattenberg Peter R. Galle Benno Weigmann Ari Waisman Elke Glasmacher Nadine Hövelmeyer
author_sort	Sonja Reißig
title	Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
title_short	Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
title_full	Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
title_fullStr	Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
title_full_unstemmed	Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
title_sort	elevated levels of bcl-3 inhibits treg development and function resulting in spontaneous colitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87d328bf46c940f9b17786b9c4f283ce
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Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

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