Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonja Reißig, Yilang Tang, Alexei Nikolaev, Katharina Gerlach, Christine Wolf, Kathrin Davari, Christian Gallus, Joumana Masri, Ilgiz A. Mufazalov, Markus F. Neurath, F. Thomas Wunderlich, Jörn M. Schattenberg, Peter R. Galle, Benno Weigmann, Ari Waisman, Elke Glasmacher, Nadine Hövelmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87d328bf46c940f9b17786b9c4f283ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Sea el primero en dejar un comentario!

Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

Ejemplares similares