Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the development of food sensitivities, independently of the...

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Autores principales: Alberto Caminero, Justin L. McCarville, Heather J. Galipeau, Celine Deraison, Steve P. Bernier, Marco Constante, Corinne Rolland, Marlies Meisel, Joseph A. Murray, Xuechen B. Yu, Armin Alaedini, Brian K. Coombes, Premysl Bercik, Carolyn M. Southward, Wolfram Ruf, Bana Jabri, Fernando G. Chirdo, Javier Casqueiro, Michael G. Surette, Nathalie Vergnolle, Elena F. Verdu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/87da3a2758a84144a45120e2dbe4b18e
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spelling oai:doaj.org-article:87da3a2758a84144a45120e2dbe4b18e2021-12-02T16:57:44ZDuodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-210.1038/s41467-019-09037-92041-1723https://doaj.org/article/87da3a2758a84144a45120e2dbe4b18e2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09037-9https://doaj.org/toc/2041-1723Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the development of food sensitivities, independently of the trigger antigen.Alberto CamineroJustin L. McCarvilleHeather J. GalipeauCeline DeraisonSteve P. BernierMarco ConstanteCorinne RollandMarlies MeiselJoseph A. MurrayXuechen B. YuArmin AlaediniBrian K. CoombesPremysl BercikCarolyn M. SouthwardWolfram RufBana JabriFernando G. ChirdoJavier CasqueiroMichael G. SuretteNathalie VergnolleElena F. VerduNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alberto Caminero
Justin L. McCarville
Heather J. Galipeau
Celine Deraison
Steve P. Bernier
Marco Constante
Corinne Rolland
Marlies Meisel
Joseph A. Murray
Xuechen B. Yu
Armin Alaedini
Brian K. Coombes
Premysl Bercik
Carolyn M. Southward
Wolfram Ruf
Bana Jabri
Fernando G. Chirdo
Javier Casqueiro
Michael G. Surette
Nathalie Vergnolle
Elena F. Verdu
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
description Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the development of food sensitivities, independently of the trigger antigen.
format article
author Alberto Caminero
Justin L. McCarville
Heather J. Galipeau
Celine Deraison
Steve P. Bernier
Marco Constante
Corinne Rolland
Marlies Meisel
Joseph A. Murray
Xuechen B. Yu
Armin Alaedini
Brian K. Coombes
Premysl Bercik
Carolyn M. Southward
Wolfram Ruf
Bana Jabri
Fernando G. Chirdo
Javier Casqueiro
Michael G. Surette
Nathalie Vergnolle
Elena F. Verdu
author_facet Alberto Caminero
Justin L. McCarville
Heather J. Galipeau
Celine Deraison
Steve P. Bernier
Marco Constante
Corinne Rolland
Marlies Meisel
Joseph A. Murray
Xuechen B. Yu
Armin Alaedini
Brian K. Coombes
Premysl Bercik
Carolyn M. Southward
Wolfram Ruf
Bana Jabri
Fernando G. Chirdo
Javier Casqueiro
Michael G. Surette
Nathalie Vergnolle
Elena F. Verdu
author_sort Alberto Caminero
title Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
title_short Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
title_full Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
title_fullStr Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
title_full_unstemmed Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
title_sort duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/87da3a2758a84144a45120e2dbe4b18e
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