Cell-derived extracellular vesicles and membranes for tissue repair

Abstract Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers...

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Autores principales:	Yuan Ding, Yanjie Li, Zhongquan Sun, Xin Han, Yining Chen, Yao Ge, Zhengwei Mao, Weilin Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cell membrane Extracellular vesicles Cell therapy Regenerative medicine Biomaterials Stem cells Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/87dc1444260e47ea8ec8daefc810ec65
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spelling	oai:doaj.org-article:87dc1444260e47ea8ec8daefc810ec652021-11-21T12:29:29ZCell-derived extracellular vesicles and membranes for tissue repair10.1186/s12951-021-01113-x1477-3155https://doaj.org/article/87dc1444260e47ea8ec8daefc810ec652021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01113-xhttps://doaj.org/toc/1477-3155Abstract Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell differentiation or regeneration is the major driving force of tissue repair. Additionally, ethical and safety problems have limited the application of stem cell therapies. Therefore, nonliving cell-derived techniques such as extracellular vesicle (EV) therapy and cell membrane-based therapy to fulfil the unmet demand for tissue repair are important. Nonliving cell-derived biomaterials are safer and more controllable, and their efficacy is easier to enhance through bioengineering approaches. Here, we described the development and evolution from cell therapy to EV therapy and cell membrane-based therapy for tissue repair. Furthermore, the latest advances in nonliving cell-derived therapies empowered by advanced engineering techniques are emphatically reviewed, and their potential and challenges in the future are discussed. Graphical AbstractYuan DingYanjie LiZhongquan SunXin HanYining ChenYao GeZhengwei MaoWeilin WangBMCarticleCell membraneExtracellular vesiclesCell therapyRegenerative medicineBiomaterialsStem cellsBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell membrane Extracellular vesicles Cell therapy Regenerative medicine Biomaterials Stem cells Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Cell membrane Extracellular vesicles Cell therapy Regenerative medicine Biomaterials Stem cells Biotechnology TP248.13-248.65 Medical technology R855-855.5 Yuan Ding Yanjie Li Zhongquan Sun Xin Han Yining Chen Yao Ge Zhengwei Mao Weilin Wang Cell-derived extracellular vesicles and membranes for tissue repair
description	Abstract Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell differentiation or regeneration is the major driving force of tissue repair. Additionally, ethical and safety problems have limited the application of stem cell therapies. Therefore, nonliving cell-derived techniques such as extracellular vesicle (EV) therapy and cell membrane-based therapy to fulfil the unmet demand for tissue repair are important. Nonliving cell-derived biomaterials are safer and more controllable, and their efficacy is easier to enhance through bioengineering approaches. Here, we described the development and evolution from cell therapy to EV therapy and cell membrane-based therapy for tissue repair. Furthermore, the latest advances in nonliving cell-derived therapies empowered by advanced engineering techniques are emphatically reviewed, and their potential and challenges in the future are discussed. Graphical Abstract
format	article
author	Yuan Ding Yanjie Li Zhongquan Sun Xin Han Yining Chen Yao Ge Zhengwei Mao Weilin Wang
author_facet	Yuan Ding Yanjie Li Zhongquan Sun Xin Han Yining Chen Yao Ge Zhengwei Mao Weilin Wang
author_sort	Yuan Ding
title	Cell-derived extracellular vesicles and membranes for tissue repair
title_short	Cell-derived extracellular vesicles and membranes for tissue repair
title_full	Cell-derived extracellular vesicles and membranes for tissue repair
title_fullStr	Cell-derived extracellular vesicles and membranes for tissue repair
title_full_unstemmed	Cell-derived extracellular vesicles and membranes for tissue repair
title_sort	cell-derived extracellular vesicles and membranes for tissue repair
publisher	BMC
publishDate	2021
url	https://doaj.org/article/87dc1444260e47ea8ec8daefc810ec65
work_keys_str_mv	AT yuanding cellderivedextracellularvesiclesandmembranesfortissuerepair AT yanjieli cellderivedextracellularvesiclesandmembranesfortissuerepair AT zhongquansun cellderivedextracellularvesiclesandmembranesfortissuerepair AT xinhan cellderivedextracellularvesiclesandmembranesfortissuerepair AT yiningchen cellderivedextracellularvesiclesandmembranesfortissuerepair AT yaoge cellderivedextracellularvesiclesandmembranesfortissuerepair AT zhengweimao cellderivedextracellularvesiclesandmembranesfortissuerepair AT weilinwang cellderivedextracellularvesiclesandmembranesfortissuerepair
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Cell-derived extracellular vesicles and membranes for tissue repair

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