Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines

Abstract Wheat grain yield (GY) improvement using genomic tools is important for achieving yield breakthroughs. To dissect the genetic architecture of wheat GY potential and stress-resilience, we have designed this large-scale genome-wide association study using 100 datasets, comprising 105,000 GY o...

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Autores principales:	Philomin Juliana, Ravi Prakash Singh, Jesse Poland, Sandesh Shrestha, Julio Huerta-Espino, Velu Govindan, Suchismita Mondal, Leonardo Abdiel Crespo-Herrera, Uttam Kumar, Arun Kumar Joshi, Thomas Payne, Pradeep Kumar Bhati, Vipin Tomar, Franjel Consolacion, Jaime Amador Campos Serna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87dc734a46b64d40ad0f76736e17ea85
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spelling	oai:doaj.org-article:87dc734a46b64d40ad0f76736e17ea852021-12-02T15:54:02ZElucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines10.1038/s41598-021-84308-42045-2322https://doaj.org/article/87dc734a46b64d40ad0f76736e17ea852021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84308-4https://doaj.org/toc/2045-2322Abstract Wheat grain yield (GY) improvement using genomic tools is important for achieving yield breakthroughs. To dissect the genetic architecture of wheat GY potential and stress-resilience, we have designed this large-scale genome-wide association study using 100 datasets, comprising 105,000 GY observations from 55,568 wheat lines evaluated between 2003 and 2019 by the International Maize and Wheat Improvement Center and national partners. We report 801 GY-associated genotyping-by-sequencing markers significant in more than one dataset and the highest number of them were on chromosomes 2A, 6B, 6A, 5B, 1B and 7B. We then used the linkage disequilibrium (LD) between the consistently significant markers to designate 214 GY-associated LD-blocks and observed that 84.5% of the 58 GY-associated LD-blocks in severe-drought, 100% of the 48 GY-associated LD-blocks in early-heat and 85.9% of the 71 GY-associated LD-blocks in late-heat, overlapped with the GY-associated LD-blocks in the irrigated-bed planting environment, substantiating that simultaneous improvement for GY potential and stress-resilience is feasible. Furthermore, we generated the GY-associated marker profiles and analyzed the GY favorable allele frequencies for a large panel of 73,142 wheat lines, resulting in 44.5 million datapoints. Overall, the extensive resources presented in this study provide great opportunities to accelerate breeding for high-yielding and stress-resilient wheat varieties.Philomin JulianaRavi Prakash SinghJesse PolandSandesh ShresthaJulio Huerta-EspinoVelu GovindanSuchismita MondalLeonardo Abdiel Crespo-HerreraUttam KumarArun Kumar JoshiThomas PaynePradeep Kumar BhatiVipin TomarFranjel ConsolacionJaime Amador Campos SernaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philomin Juliana Ravi Prakash Singh Jesse Poland Sandesh Shrestha Julio Huerta-Espino Velu Govindan Suchismita Mondal Leonardo Abdiel Crespo-Herrera Uttam Kumar Arun Kumar Joshi Thomas Payne Pradeep Kumar Bhati Vipin Tomar Franjel Consolacion Jaime Amador Campos Serna Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
description	Abstract Wheat grain yield (GY) improvement using genomic tools is important for achieving yield breakthroughs. To dissect the genetic architecture of wheat GY potential and stress-resilience, we have designed this large-scale genome-wide association study using 100 datasets, comprising 105,000 GY observations from 55,568 wheat lines evaluated between 2003 and 2019 by the International Maize and Wheat Improvement Center and national partners. We report 801 GY-associated genotyping-by-sequencing markers significant in more than one dataset and the highest number of them were on chromosomes 2A, 6B, 6A, 5B, 1B and 7B. We then used the linkage disequilibrium (LD) between the consistently significant markers to designate 214 GY-associated LD-blocks and observed that 84.5% of the 58 GY-associated LD-blocks in severe-drought, 100% of the 48 GY-associated LD-blocks in early-heat and 85.9% of the 71 GY-associated LD-blocks in late-heat, overlapped with the GY-associated LD-blocks in the irrigated-bed planting environment, substantiating that simultaneous improvement for GY potential and stress-resilience is feasible. Furthermore, we generated the GY-associated marker profiles and analyzed the GY favorable allele frequencies for a large panel of 73,142 wheat lines, resulting in 44.5 million datapoints. Overall, the extensive resources presented in this study provide great opportunities to accelerate breeding for high-yielding and stress-resilient wheat varieties.
format	article
author	Philomin Juliana Ravi Prakash Singh Jesse Poland Sandesh Shrestha Julio Huerta-Espino Velu Govindan Suchismita Mondal Leonardo Abdiel Crespo-Herrera Uttam Kumar Arun Kumar Joshi Thomas Payne Pradeep Kumar Bhati Vipin Tomar Franjel Consolacion Jaime Amador Campos Serna
author_facet	Philomin Juliana Ravi Prakash Singh Jesse Poland Sandesh Shrestha Julio Huerta-Espino Velu Govindan Suchismita Mondal Leonardo Abdiel Crespo-Herrera Uttam Kumar Arun Kumar Joshi Thomas Payne Pradeep Kumar Bhati Vipin Tomar Franjel Consolacion Jaime Amador Campos Serna
author_sort	Philomin Juliana
title	Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
title_short	Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
title_full	Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
title_fullStr	Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
title_full_unstemmed	Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
title_sort	elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87dc734a46b64d40ad0f76736e17ea85
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Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines

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