Identification of dynamic undifferentiated cell states within the male germline

Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the transcription factor PDX1 and has stem cell capacity.

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Autores principales:	Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87e119b967464304a757f01694a020cf
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spelling	oai:doaj.org-article:87e119b967464304a757f01694a020cf2021-12-02T15:34:17ZIdentification of dynamic undifferentiated cell states within the male germline10.1038/s41467-018-04827-z2041-1723https://doaj.org/article/87e119b967464304a757f01694a020cf2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04827-zhttps://doaj.org/toc/2041-1723Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the transcription factor PDX1 and has stem cell capacity.Hue M. LaJuho-Antti MäkeläAi-Leen ChanFernando J. RosselloChristian M. NefzgerJulien M. D. LegrandMia De SeramJose M. PoloRobin M. HobbsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hue M. La Juho-Antti Mäkelä Ai-Leen Chan Fernando J. Rossello Christian M. Nefzger Julien M. D. Legrand Mia De Seram Jose M. Polo Robin M. Hobbs Identification of dynamic undifferentiated cell states within the male germline
description	Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the transcription factor PDX1 and has stem cell capacity.
format	article
author	Hue M. La Juho-Antti Mäkelä Ai-Leen Chan Fernando J. Rossello Christian M. Nefzger Julien M. D. Legrand Mia De Seram Jose M. Polo Robin M. Hobbs
author_facet	Hue M. La Juho-Antti Mäkelä Ai-Leen Chan Fernando J. Rossello Christian M. Nefzger Julien M. D. Legrand Mia De Seram Jose M. Polo Robin M. Hobbs
author_sort	Hue M. La
title	Identification of dynamic undifferentiated cell states within the male germline
title_short	Identification of dynamic undifferentiated cell states within the male germline
title_full	Identification of dynamic undifferentiated cell states within the male germline
title_fullStr	Identification of dynamic undifferentiated cell states within the male germline
title_full_unstemmed	Identification of dynamic undifferentiated cell states within the male germline
title_sort	identification of dynamic undifferentiated cell states within the male germline
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/87e119b967464304a757f01694a020cf
work_keys_str_mv	AT huemla identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT juhoanttimakela identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT aileenchan identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT fernandojrossello identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT christianmnefzger identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT julienmdlegrand identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT miadeseram identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT josempolo identificationofdynamicundifferentiatedcellstateswithinthemalegermline AT robinmhobbs identificationofdynamicundifferentiatedcellstateswithinthemalegermline
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Identification of dynamic undifferentiated cell states within the male germline

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