Serum levels of GPER -1 in euthymic bipolar patients

Fatma Özlem Orhan,1 Ergül Belge Kurutaş,2 Adem Doğaner,3 Ebru Türker,1 Safiye Şeyma Taner Özcü,4 Meltem Güngör,5 Seyfettin Çakmak1 1Department of Psychiatry, Faculty of Medicine, Kahramanmaraş Sütç&uum...

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Autores principales:	Orhan FÖ, Kurutaş EB, Doğaner A, Türker E, Taner Özcü SŞ, Güngör M, Çakmak S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Estrogen receptor Sex hormones GPER-1 Bipolar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/87e1d196318447ddab3a157b2597efd8
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spelling	oai:doaj.org-article:87e1d196318447ddab3a157b2597efd82021-12-02T05:11:25ZSerum levels of GPER -1 in euthymic bipolar patients1178-2021https://doaj.org/article/87e1d196318447ddab3a157b2597efd82018-03-01T00:00:00Zhttps://www.dovepress.com/serum-levels-of-gper--1-in-euthymic-bipolar-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fatma Özlem Orhan,1 Ergül Belge Kurutaş,2 Adem Doğaner,3 Ebru Türker,1 Safiye Şeyma Taner Özcü,4 Meltem Güngör,5 Seyfettin Çakmak1 1Department of Psychiatry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 2Department of Biochemistry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 3Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 4Department of Bioengineering, Institute of Science, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 5Vocational High School, Toros University, Mersin, Turkey Introduction: Estrogen and its receptors have been suggested as playing a role in the pathogenesis of bipolar disorder (BD). Estrogen functions through the estrogen receptors alpha and beta and the recently discovered G-protein–coupled estrogen receptor-1 (GPER-1). The aim of this study was to evaluate serum GPER-1 levels in euthymic BD patients. Patients and methods: The study population consisted of 38 euthymic outpatients meeting the criteria for BD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and 35 age- and gender-matched healthy controls. Medical histories were obtained and physical examinations and laboratory tests conducted. Results: Serum GPER-1 levels were measured in both patients and controls and found to be significantly higher in the BD patients than in controls. These results were not influenced by the medications in use. Conclusion: The results of this study demonstrated that GPER-1 may play a role in BD pathophysiology. Keywords: estrogen receptor, sex hormones, GPER-1, bipolar, euthymicOrhan FÖKurutaş EBDoğaner ATürker ETaner Özcü SŞGüngör MÇakmak SDove Medical PressarticleEstrogen receptorSex hormonesGPER-1BipolarNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 855-862 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Estrogen receptor Sex hormones GPER-1 Bipolar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Estrogen receptor Sex hormones GPER-1 Bipolar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Orhan FÖ Kurutaş EB Doğaner A Türker E Taner Özcü SŞ Güngör M Çakmak S Serum levels of GPER -1 in euthymic bipolar patients
description	Fatma Özlem Orhan,1 Ergül Belge Kurutaş,2 Adem Doğaner,3 Ebru Türker,1 Safiye Şeyma Taner Özcü,4 Meltem Güngör,5 Seyfettin Çakmak1 1Department of Psychiatry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 2Department of Biochemistry, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 3Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 4Department of Bioengineering, Institute of Science, Kahramanmaraş Sütçüimam University, Kahramanmaras, Turkey; 5Vocational High School, Toros University, Mersin, Turkey Introduction: Estrogen and its receptors have been suggested as playing a role in the pathogenesis of bipolar disorder (BD). Estrogen functions through the estrogen receptors alpha and beta and the recently discovered G-protein–coupled estrogen receptor-1 (GPER-1). The aim of this study was to evaluate serum GPER-1 levels in euthymic BD patients. Patients and methods: The study population consisted of 38 euthymic outpatients meeting the criteria for BD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and 35 age- and gender-matched healthy controls. Medical histories were obtained and physical examinations and laboratory tests conducted. Results: Serum GPER-1 levels were measured in both patients and controls and found to be significantly higher in the BD patients than in controls. These results were not influenced by the medications in use. Conclusion: The results of this study demonstrated that GPER-1 may play a role in BD pathophysiology. Keywords: estrogen receptor, sex hormones, GPER-1, bipolar, euthymic
format	article
author	Orhan FÖ Kurutaş EB Doğaner A Türker E Taner Özcü SŞ Güngör M Çakmak S
author_facet	Orhan FÖ Kurutaş EB Doğaner A Türker E Taner Özcü SŞ Güngör M Çakmak S
author_sort	Orhan FÖ
title	Serum levels of GPER -1 in euthymic bipolar patients
title_short	Serum levels of GPER -1 in euthymic bipolar patients
title_full	Serum levels of GPER -1 in euthymic bipolar patients
title_fullStr	Serum levels of GPER -1 in euthymic bipolar patients
title_full_unstemmed	Serum levels of GPER -1 in euthymic bipolar patients
title_sort	serum levels of gper -1 in euthymic bipolar patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/87e1d196318447ddab3a157b2597efd8
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Serum levels of GPER -1 in euthymic bipolar patients

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