Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma

Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development. One of the most prevalent RNA modificat...

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Autores principales:	Xiao Yu, Qiyao Zhang, Fang Gao, Menggang Zhang, Qingyuan Zheng, Yuting He, Wenzhi Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87e3813bac7144f3a91f82d526279e28
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spelling	oai:doaj.org-article:87e3813bac7144f3a91f82d526279e282021-12-02T19:09:20ZPredictive value of m5C regulatory gene expression in pancreatic adenocarcinoma10.1038/s41598-021-96470-w2045-2322https://doaj.org/article/87e3813bac7144f3a91f82d526279e282021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96470-whttps://doaj.org/toc/2045-2322Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development. One of the most prevalent RNA modifications is 5-methylcytosine (m5C); however, its contribution to PAAD remains unclear. Data from The Cancer Genome Atlas (TCGA) database, including genes, copy number variations (CNVs), and simple nucleotide variations (SNVs), were obtained in the present study to identify gene signatures and prognostic values for m5C regulators in PAAD. Regulatory gene m5C changes were significantly correlated with TP53, BRCA1, CDKN2A, and ATM genes, which play important roles in PAAD pathogenesis. In particular, there was a significant relationship between m5C regulatory gene CNVs, especially in genes encoding epigenetic “writers”. According to m5C-regulated gene expression in clinically graded cases, one m5C-regulated genes, DNMT3A, showed both a strong effect on CNVs and a significant correlation between expression level and clinical grade (P < 0.05). Furthermore, low DNMT3A expression was not only associated with poor PAAD patient prognosis but also with the ribosomal processing. The relationship between low DNMT3A expression and poor prognosis was confirmed in an International Cancer Genome Consortium (ICGC) validation dataset.Xiao YuQiyao ZhangFang GaoMenggang ZhangQingyuan ZhengYuting HeWenzhi GuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiao Yu Qiyao Zhang Fang Gao Menggang Zhang Qingyuan Zheng Yuting He Wenzhi Guo Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
description	Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development. One of the most prevalent RNA modifications is 5-methylcytosine (m5C); however, its contribution to PAAD remains unclear. Data from The Cancer Genome Atlas (TCGA) database, including genes, copy number variations (CNVs), and simple nucleotide variations (SNVs), were obtained in the present study to identify gene signatures and prognostic values for m5C regulators in PAAD. Regulatory gene m5C changes were significantly correlated with TP53, BRCA1, CDKN2A, and ATM genes, which play important roles in PAAD pathogenesis. In particular, there was a significant relationship between m5C regulatory gene CNVs, especially in genes encoding epigenetic “writers”. According to m5C-regulated gene expression in clinically graded cases, one m5C-regulated genes, DNMT3A, showed both a strong effect on CNVs and a significant correlation between expression level and clinical grade (P < 0.05). Furthermore, low DNMT3A expression was not only associated with poor PAAD patient prognosis but also with the ribosomal processing. The relationship between low DNMT3A expression and poor prognosis was confirmed in an International Cancer Genome Consortium (ICGC) validation dataset.
format	article
author	Xiao Yu Qiyao Zhang Fang Gao Menggang Zhang Qingyuan Zheng Yuting He Wenzhi Guo
author_facet	Xiao Yu Qiyao Zhang Fang Gao Menggang Zhang Qingyuan Zheng Yuting He Wenzhi Guo
author_sort	Xiao Yu
title	Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
title_short	Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
title_full	Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
title_fullStr	Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
title_full_unstemmed	Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
title_sort	predictive value of m5c regulatory gene expression in pancreatic adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87e3813bac7144f3a91f82d526279e28
work_keys_str_mv	AT xiaoyu predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT qiyaozhang predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT fanggao predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT menggangzhang predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT qingyuanzheng predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT yutinghe predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma AT wenzhiguo predictivevalueofm5cregulatorygeneexpressioninpancreaticadenocarcinoma
_version_	1718377100210077696

Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma

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