Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Antimicrobial susceptibility testing standards driving clinical decision-making have centered around the use of cation-adjusted Mueller-Hinton broth (CA-MHB) as the medium with the notion of supporting bacterial growth, without consideration of recapitulating the in vivo environment. Howeve...

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Bibliographic Details
Main Authors: Michael J. Salazar, Henrique Machado, Nicholas A. Dillon, Hannah Tsunemoto, Richard Szubin, Samira Dahesh, Joseph Pogliano, George Sakoulas, Bernhard O. Palsson, Victor Nizet, Adam M. Feist
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Staphylococcus aureus
antibiotic resistance
nafcillin
USA300
adaptive laboratory evolution
drug resistance mechanisms
Microbiology
QR1-502
Online Access:https://doaj.org/article/87e85fc604b34bc8ba13b69e385db06f
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