Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes

Abstract Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria f...

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Autores principales:	Yea-Seul Han, Sung-Ha Kim, Tae-Jung Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87e8bb58514c4bd8afeb3311ceaf5ec8
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spelling	oai:doaj.org-article:87e8bb58514c4bd8afeb3311ceaf5ec82021-11-21T12:19:57ZImpact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes10.1038/s41598-021-01219-02045-2322https://doaj.org/article/87e8bb58514c4bd8afeb3311ceaf5ec82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01219-0https://doaj.org/toc/2045-2322Abstract Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24+0 and < 32+0 weeks gestation from January 2013 to December 2015 were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.Yea-Seul HanSung-Ha KimTae-Jung SungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yea-Seul Han Sung-Ha Kim Tae-Jung Sung Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
description	Abstract Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24+0 and < 32+0 weeks gestation from January 2013 to December 2015 were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.
format	article
author	Yea-Seul Han Sung-Ha Kim Tae-Jung Sung
author_facet	Yea-Seul Han Sung-Ha Kim Tae-Jung Sung
author_sort	Yea-Seul Han
title	Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
title_short	Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
title_full	Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
title_fullStr	Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
title_full_unstemmed	Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
title_sort	impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87e8bb58514c4bd8afeb3311ceaf5ec8
work_keys_str_mv	AT yeaseulhan impactofthedefinitionofbronchopulmonarydysplasiaonneurodevelopmentaloutcomes AT sunghakim impactofthedefinitionofbronchopulmonarydysplasiaonneurodevelopmentaloutcomes AT taejungsung impactofthedefinitionofbronchopulmonarydysplasiaonneurodevelopmentaloutcomes
_version_	1718419076271833088

Impact of the definition of bronchopulmonary dysplasia on neurodevelopmental outcomes

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