A Personal Account on Industrial Collaborations in the Field of C–H Activation

In recent years, transition-metal-catalyzed C–H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaboratio...

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Autor principal:	Olivier Baudoin
Formato:	article
Lenguaje:	DE EN FR
Publicado:	Swiss Chemical Society 2021
Materias:	bioactive molecules catalysis c-h activation palladium Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/87e964336f1247f38c398c33d2bfd7b6
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id	oai:doaj.org-article:87e964336f1247f38c398c33d2bfd7b6
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spelling	oai:doaj.org-article:87e964336f1247f38c398c33d2bfd7b62021-11-26T10:14:11ZA Personal Account on Industrial Collaborations in the Field of C–H Activation10.2533/chimia.2021.9670009-42932673-2424https://doaj.org/article/87e964336f1247f38c398c33d2bfd7b62021-11-01T00:00:00Zhttps://doaj.org/toc/0009-4293https://doaj.org/toc/2673-2424In recent years, transition-metal-catalyzed C–H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaborations in C(sp3)–H bond activation, which were key to the development of this topic in our group. The synthesis of the antianginal drug Ivabradine led us to develop a general approach to benzocyclobutenes, which were further employed in peri cyclic reactions. A follow-up study led us to discover a new method to construct arylcyclopropanes via double C–H activation and the coupling of two alkyl groups. Finally, targeting the herbicide Indaziflam contributed to develop C(sp3)–H activation as a powerful tool to access a variety of relevant indane motifs. We hope that these successful stories will help to stimulate further fruitful Industry-Academia collaborations in the field of synthetic chemistry.Olivier BaudoinSwiss Chemical Societyarticlebioactive moleculescatalysisc-h activationpalladiumChemistryQD1-999DEENFRCHIMIA, Vol 75, Iss 11, Pp 967-971 (2021)
institution	DOAJ
collection	DOAJ
language	DE EN FR
topic	bioactive molecules catalysis c-h activation palladium Chemistry QD1-999
spellingShingle	bioactive molecules catalysis c-h activation palladium Chemistry QD1-999 Olivier Baudoin A Personal Account on Industrial Collaborations in the Field of C–H Activation
description	In recent years, transition-metal-catalyzed C–H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaborations in C(sp3)–H bond activation, which were key to the development of this topic in our group. The synthesis of the antianginal drug Ivabradine led us to develop a general approach to benzocyclobutenes, which were further employed in peri cyclic reactions. A follow-up study led us to discover a new method to construct arylcyclopropanes via double C–H activation and the coupling of two alkyl groups. Finally, targeting the herbicide Indaziflam contributed to develop C(sp3)–H activation as a powerful tool to access a variety of relevant indane motifs. We hope that these successful stories will help to stimulate further fruitful Industry-Academia collaborations in the field of synthetic chemistry.
format	article
author	Olivier Baudoin
author_facet	Olivier Baudoin
author_sort	Olivier Baudoin
title	A Personal Account on Industrial Collaborations in the Field of C–H Activation
title_short	A Personal Account on Industrial Collaborations in the Field of C–H Activation
title_full	A Personal Account on Industrial Collaborations in the Field of C–H Activation
title_fullStr	A Personal Account on Industrial Collaborations in the Field of C–H Activation
title_full_unstemmed	A Personal Account on Industrial Collaborations in the Field of C–H Activation
title_sort	personal account on industrial collaborations in the field of c–h activation
publisher	Swiss Chemical Society
publishDate	2021
url	https://doaj.org/article/87e964336f1247f38c398c33d2bfd7b6
work_keys_str_mv	AT olivierbaudoin apersonalaccountonindustrialcollaborationsinthefieldofchactivation AT olivierbaudoin personalaccountonindustrialcollaborationsinthefieldofchactivation
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A Personal Account on Industrial Collaborations in the Field of C–H Activation

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